超临界CO_2-分子蒸馏制备大蒜注射液  

Preparation of Garlic injection by SFE-CO_2 and MD

作　　者：张忠义[1] 雷正杰[1] 黄昌全[1] 古维新[1] 王桂芳[1] 

机构地区：[1]第一军医大学珠江医院,广东广州510282

出　　处：《中国医院药学杂志》2002年第10期581-582,共2页Chinese Journal of Hospital Pharmacy

基　　金：广东省科技攻关项目 ( 2KB0 12 0 2 5 )

摘　　要：目的 :在低温 (6 0℃以下 )条件下制备大蒜注射液。方法 :超临界CO2 对大蒜有效成分进行萃取 ,用分子蒸馏进行分离纯化 ,用超滤法过滤除菌。结果 :注射液的各项指标符合中国药典 2 0 0 0年版附录IB注射剂项下的各项规定。结论 :超临界CO2OBJECTIVE To prepare Garlic injection at the temperature below 60℃.METHODS The effective components of Garlic were extracted by supercritical CO 2 fluid extraction(SFE-CO 2), separated and purified by molecular distillation(MD). And then they were filtrated by ultrafiltration to get sterile injection.RESULTS Quality of the injection met with the standards for injections of appendix IB in Chinese pharmacopoeia. CONCLUSIONS Preparation of Garlic injection by SFE-CO 2 and MD is a fairly advanced and rational method.

关 键 词：大蒜注射剂 超临界CO2萃取 分子蒸馏 超滤 

分 类 号：R282.71[医药卫生—中药学]