分泌性中耳炎豚鼠模型咽鼓管表面活性物质的研究  

Surfactants in Eustachian tube of guinea pigs with secretory otitis media

作　　者：廖志苏[1] 陈超[2] 杜瀚[1] 吴秀玲[1] 朱金昌[1] 李智渊[1] 

机构地区：[1]温州医学院附属第一医院,325000 [2]复旦大学附属儿童医院

出　　处：《浙江医学》2002年第9期522-523,共2页Zhejiang Medical Journal

摘　　要：目的 研究分泌性中耳炎时咽鼓管表面活性物质的变化 ,为分泌性中耳炎的治疗提供客观依据。方法 将灭活的肺炎链球菌悬液注入豚鼠鼓室 ,制成豚鼠分泌性中耳炎动物模型 ,然后取出正常组和模型组豚鼠咽鼓管 ,测定及分析两组豚鼠咽鼓管表面活性物质。结果 对照组与模型组豚鼠咽鼓管表面活性物质主要生化成分的差别有显著性意义 ,模型组咽鼓管表面活性物质主要生化成分磷脂酰胆碱 (PC)和磷脂酰乙醇胺 (PE)明显减少(均P<0.001) ,其活性也明显下降 (P<0.001)。 结论 分泌性中耳炎时咽鼓管表面活性物质主要成分的减少和活性下降 。Objective To investigate the changes of surfactants in secretory otitis media of guinea pigs to provide experimental basis for clinical treatment of the disease. Methods Tympanic cavities of guinea pig were injected with inactivated streptococcus pneumoniae, resulting in an animal model of secretory otitis media.Results Main biochemical components of surfactants in secretory otitis media, such as phosphatidylcholine(PC )and phosphatidylethanolamina(PE) significantly decreased, compared with those in normal animals (P<0.001).Conclusion The main component of surfactants of Eustachian tube decreased in secretory otitis media of guinea pig, which may be an important cause of this disease.

关 键 词：分泌性中耳炎 豚鼠 咽鼓管 表面活性物质 治疗 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]