中药肾病合剂减少儿童单纯型肾病综合征复发的临床研究  

Clinical Study on Effect of Shenbing Mixture in Reducing Recurrence of Simple Nephrotic Syndrome of Children

作　　者：李新民[1] 马融[1] 李少川[1] 孙希焕[1] 郝瑞芳[1] 任勤[1] 胡淑萍[1] 袁志毅[1] 

机构地区：[1]天津中医学院第一附属医院,天津300193

出　　处：《中国中西医结合杂志》2002年第9期650-653,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：天津市教委资助项目 (No .930 30 1 7)

摘　　要：目的 :观察中药肾病合剂对儿童单纯型肾病综合征复发的影响。方法 :以肾病合剂配合强的松治疗儿童单纯型肾病综合征 6 8例 (中西药组 ) ,并随机设立强的松组 33例 (西药组 ) ,进行对照研究。结果 :1年复发率中西药组为 14 3% ,对照组为 5 9 3% ,中西药组明显低于对照组 (P <0 0 1)。患儿治疗前血清皮质醇、IgG、IgA及CD3、CD4 、CD4 /CD8、红细胞C3b受体花环率均明显低于健康组 (P <0 0 1或P <0 0 5 ) ;中西药组患儿治疗 6个月后 ,上述指标均明显上升 ,与健康组比较差异无显著性。结论 :肾病合剂可减少肾病复发 ,其作用机制与其调整T细胞功能紊乱 ,改善体液免疫和红细胞免疫功能及促进肾上腺皮质功能恢复等多种途径有关。Objective: To observe the effect of Shenbing Mixture (SBM) of the recurrence of simple nephrotic syndrome of children. Methods: Sixty eight patients treated with SBM combined with prednisone were observed and compared with that in the control group treated with prednisone only. Results: The 1 year recurrence rate of the treated group was 14.3%, which was obviously lower than that in the control group (P<0 01). Serum level of cortisol, IgG, IgA, CD 3, CD 4, CD 4/CD 8 ratio and rosette formation rate of RBC C 3b in patients before treatment were all significantly lower than normal range. After being treated with SBM combined with prednisone, the above mentioned indexes were all improved significantly and close to normal. Conclusion: SBM had obvious effect in reducing recurrence of nephrotic syndrome in children, the mechanism is closely related to multiple pathways, including adjustment of T lymphocyte dysfunction, improving humoral immunity and RBC immune function, and promoting the recovery of adrenal cortex function.

关 键 词：中医药疗法 肾病合剂 儿童 单纯型肾病综合征 复发 临床研究 

分 类 号：R277.592[医药卫生—中医学]