维生素D受体基因多态性与银屑病的关系  

The Association between Vitamin D Receptor Polymorphism and Psoriasis

作　　者：朱慧琴[1] 陈玲娣[1] 朱光斗[1] 谢匡成[2] 

机构地区：[1]上海市第一人民医院皮肤科 [2]上海市第一人民医院中心实验室

出　　处：《中华皮肤科杂志》2002年第5期386-388,共3页Chinese Journal of Dermatology

基　　金：中华医学会皮肤科学会科研基金资助课题(2000年度杨森基金)

摘　　要：目的探讨维生素D受体(VDR)基因多态性与银屑病的关系。方法采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP),对112例无血缘关系的银屑病患者和108例无血缘关系的健康人员的VDR基因型进行分析。结果AA、Bb基因型在健康人中出现的频率仅7.4%及14.8%,而在银屑病人中出现的频率为19.6%及32.1%。进一步分析VDR基因型与银屑病患者性别、发病年龄、家族史等的关系,未发现显著相关。在统计等位基因A、a和B、b时,发现它们在两组人群中出现的频率差异均无显著性。结论维生素D受体(VDR)基因型分布在银屑病患者与健康人中是显著不同的,纯合子AA基因型或杂合子Bb基因型的出现可能增加患银屑病的易患性。Objective To study the correlation between vitamin D receptor(VDR)polymorphism and psoriasis in the Chinese patients.Methods VDR genotypes were determined by PCR-RFLP in 112unrelated psoriatic patients as well as 108unr elated healthy controls.Results AA and Bb genotypes were found to be ex-pressed more frequently in psoriatic patients(19.6%and 32.1%)than those in normal controls(7.4%and14.8%),respectively.However,no signifi cant correlation was identified between VDR polymorphismand sex,age at onset,family history of psoriasis in psoriatic patients.In addition,there was no significant difference in the fre-quency of A,a alleles and B,b alleles between normal controls and psoriatic patients.Conclusions There is a significant difference in VDR genotypes between psoriatic patients and normal controls.The presence of hom ozygote AA or heterozygote Bb might contribute to the susceptibility of psoriasis.

关 键 词：骨化三醇受体 聚合酶链反应 维生素D受体 基因多态性 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]