前列平胶囊的抗前列腺增生作用  

The resistant effect of Qianlieping capsule on benign prostatic hyperplasia

作　　者：师晨霞[1] 孟祥琴[1] 郭芳[1] 刘秀书[1] 郭鸣放[1] 宋建徽[1] 张永健[1] 王永利[1] 

机构地区：[1]河北医科大学基础医学院药理学教研室,050017

出　　处：《河北医药》2002年第9期693-695,共3页Hebei Medical Journal

摘　　要：目的　通过动物模型观察前列平胶囊的抗前列腺增生作用。方法　使用大鼠和小鼠前列腺增生模型及角叉菜胶炎症模型。结果　前列平胶囊 0 .1g、0 .3g和 1.0g kg对小鼠尿生殖窦植入性前列腺增生模型可剂量依赖性地抑制前列腺重量系数 (分别为 11.7mg、8.2mg和 2 .3mg) (P <0 .0 1)前列腺DNA含量 (分别为 0 .172、0 .14 7和 0 .0 67OD 10g体重 ) (P <0 .0 5和 0 .0 1)。病理组织学检查表明 ,前列平胶囊可减少前列腺腺体增生数 (P <0 .0 1)、增加扩张萎缩腺体数 (P <0 .0 5和 0 .0 1)和萎缩腺体数 ;对去睾丸小鼠 ,由丙酸睾丸素所致的前列腺增生 ,前列平胶囊无明显对抗作用 (P >0 .0 5 )。前列平胶囊可降低角叉菜胶所致大鼠足跖炎性肿胀 (P <0 .0 5 )。结论　前列平胶囊具有明显抗前列腺增生作用。Objective To observe the resistant effect of Qianlieping capsule on benign prostatic hyperplasia (BPH) in animal models.Methods Experimental BPH was induced in mice and rats,and carrageenin was used to induce inflammation.Results In the BPH model of urogenital sinus transplanting mice,0.1 g,0.3 g and 1.0 g/kg of Qianlieping capsule can reduce significantly weight coefficient of prostate (11.7 mg,8.2 mg and 2.3 mg respectively) (P<0.01) and DNA quantity of prostate (0.172,0.147 and 0.067 OD/10 g weight, respectively) (P<0.05 and 0.01) in concentration dependent manner.It was observed from histopathological tissue that Qianlieping capsule decreased the quantities of hypertrophy prostate gland (P<0.01) and increased those of extendible shriveling glands (P<0.05 and 0.01) and shriveling glands;There was no significant difference between Qianlieping group and the control group in BPH induced by testosterone propionate in testis excised rats (P>0.05).Qianlieping capsule reduced paw edema and auricle edema induced by carrageenin in rats.Conculsion Qianlieping capsule has resistant effect on BPH.

关 键 词：前列平胶囊 前列腺增生 药理学 BPH 中药疗法 

分 类 号：R277.573.2[医药卫生—中医学]