微波作用下1,5-苯并硫氮杂棓-α-氨基-β-内酰胺衍生物的合成及晶体结构  

Synthesis and Crystal Structure of β-Lactam Derivatives of 1,5-Benzothiazepines under Microwave Irradition

作　　者：张萍[1] 郭秀斌[2] 宋志毅[1] 董玉环[3] 李媛[1] 

机构地区：[1]河北师范大学化学系,石家庄050016 [2]河北师范大学化工研究所,石家庄050091 [3]唐山师范学院化学系,唐山063000

出　　处：《有机化学》2002年第9期642-645,共4页Chinese Journal of Organic Chemistry

基　　金：河北省自然科学基金 (No .2 0 0 15 4)资助项目

摘　　要：甘氨酸N 端保护试剂邻苯二甲酰亚胺乙酰氯、1,5 苯并硫氮杂在三乙胺的存在下 ,用微波辐射合成了 5个1,5 苯并硫氮杂 α 氨基 β 内酰胺衍生物 ,反应在 6min内完成 ,产率较为满意 .X射线衍射分析确定了产物的立体结构 .结果表明 ,微波辐射下的反应为立体专一性反应 ,βA series of β lactam derivatives of 1,5 benzothiazepines were synthesized by the reaction of 1,5 benzothiazepines with phthalimidoacetyl chloride under microwave irradiation conditions. The reactions were completed in 6 min with good yields. The configuration and conformation of the products were determined by X ray crystal analysis. The results reveal that the reaction under microwave irradiation conditions is stereospecific. The two substituents at the β lactam are cis to each other.

关 键 词：1 5-苯并硫氮杂Zhuo-α-氨基-β-内酰胺衍生物 合成 晶体结构 微波辐射 有机合成 

分 类 号：O626[理学—有机化学] O621.392[理学—化学]