牦牛致病性大肠杆菌多价油佐剂灭活苗的初步研制  

Development of Polyvalent Oil-adjuvant Inactivated Vaccine Against Pathogenic Escherichia coli from Yak

作　　者：陈明勇[1] 张冰[1] 赵立红[1] 曾群辉[2] 

机构地区：[1]中国农业大学动物医学院,北京100094 [2]西藏农牧学院,西藏林芝860000

出　　处：《中国兽药杂志》2002年第10期11-12,共2页Chinese Journal of Veterinary Drug

基　　金：农业部畜牧业高新技术及产业化项目(牧高新99-03); 西藏自治区科委重点科技项目资助

摘　　要：本研究在分离出牦牛致病性大肠杆菌并鉴定其血清型之后,筛选出2株致病力强、免疫原性好、具有优势血清型(O142、O148、O158)的大肠杆菌菌株作为制苗菌株,以油为佐剂,研制出的牦牛致病性大肠杆菌多价油佐剂灭活苗对家兔使用安全,免疫效果好。4 ℃冰箱至少保存12个月。Based on the serotype identification of pathogenic E. coli from yak, two different serotype strains withstrong pathogenicity and good antigenicity were selected as candidate strains. Polyvalent oil-adjuvant inactivated vac-cine was prepared. The developed vaccine had good immunogenicity and could be used safely in rabbit. The duration ofpreservation at 4℃ lasted for 12 months.

关 键 词：牦牛 致病性大肠杆菌 多价油佐剂灭活苗 研制 

分 类 号：S858.23[农业科学—临床兽医学] S859.797[农业科学—兽医学]