黄体酮红外光谱的溶剂效应  

Solvent Effect in the Infrared Spectra of Progesterone

作　　者：王小燕[1] 刘清[2] 

机构地区：[1]温州大学应用技术学院,温州325027 [2]浙江大学化学系,杭州310027

出　　处：《分析化学》2002年第10期1206-1209,共4页Chinese Journal of Analytical Chemistry

摘　　要：报道在 12种极性或非极性溶剂中黄体酮红外光谱的溶剂诱导频率效应 (SIFS)。结果表明 :黄体酮C3位和C2 0 位羰基的伸缩振动频率均与溶剂AN值相关良好 ,与溶剂极性参数Y和极化率参数Π相关较差。The solvent induced frequency shifts(SIFS) observed in the infrared spectra of progesterone as a dilute solute are reported in 12 different organic solvents, both polar and non-polar. The No. 3 and No. 20 C=O stretching frequencies of progesterone show strong correlation with the acceptor number(AN) of the solvent for Lewis acidity, but not good correlation with the solvent polarity and solvent polarizability (II). The nu (C=O) frequencies are affected by intermolecular hydrogen bonding and steric effects of both the solvent and solute.

关 键 词：傅里叶变换红外光谱 溶剂效应 相关分析 黄体酮 孕激素类药物 

分 类 号：O657.3[理学—分析化学]