免疫抑制剂用量对肾移植受者细胞因子谱系的影响  

Study on the cytokine profiles in long term renal transplant recipients with different dosage of immunosuppressant

作　　者：肖家全[1] 唐孝达[1] 谭建明[1] 周佩军[1] 凡杰[1] 丁言德[1] 沈瑾[1] 

机构地区：[1]上海市第一人民医院泌尿外科上海市器官移植研究中心,200080

出　　处：《中华器官移植杂志》2002年第5期269-272,共4页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金资助项目(3 9870 70 6)

摘　　要：目的　探讨长期使用不同剂量的免疫抑制剂对肾移植受者细胞因子谱系的影响。方法　采用多种高灵敏度试剂盒 ,分别对存活 3年以上 ,且长期使用低剂量免疫抑制剂者 (低剂量组 )、使用常规剂量者 (常规组 )和慢性移植肾功能丧失者 (失功组 )的外周血多种细胞因子进行检测 ,分析细胞因子谱系的变化与临床用药量和移植效果的关系。结果　长期存活且肾功能正常者的白细胞介素4(IL 4)水平升高 ,在低剂量组升高尤其明显 ,而失功组明显降低 ;各组白细胞介素 2受体 (IL 2R)水平移植后均有升高 ,但低剂量组与正常人接近 ,失功组升高最明显 ;各组白细胞介素 1 0 (IL 1 0 )和转化生长因子 β1移植后均下降 ,前者在低剂量组和常规组中水平相近 ,后者以失功组下降最为明显。 结论　细胞因子谱系与免疫抑制剂的用量和移植肾功能有关 ,监测IL 2R和ILObjective To investigate the immunological characteristics in long term renal transplant recipients with different dosage of immunosuppression. Methods The levels of cytokines in renal transplat recipients surviving more than 3 years with low dosage of immunosuppressant (RLD group),with conventional dosage of immunosuppressant (RCD group) and in recipients with chronic allograft dysfunction (RCAF group) were detected by a high sensitive method. The relationships between cytokine level and dosage of immunosuppressant and allograft function were analyzed. Results The level of IL 4 in RLD group was increased significantly in comparison with RCD group. The level of IL 2R was similar to the normal person in RLD group,but much higher in RCD group and RCAF group.The levels of TGF β1 and IL 10 were decreased in all recipients. Conclusion The levels of IL 4 and IL 2R can be used as parameters to evaluate the immunosuppressive status in long term renal transplant recipients and may be used to optimize immunosuppressive regime.

关 键 词：肾移植 监测 免疫学 免疫因子 

分 类 号：R969[医药卫生—药理学]