5-正己基-2-巯基-1,3,4-噁二唑合成研究  

Research of Synthesis of 5-Hexyl-2-mercapto-1,3,4-oxadiazole

作　　者：冯玉君 李自力 谢存明 李燕国 

机构地区：[1]河南省化工研究所,河南郑州450052

出　　处：《河南化工》2002年第10期15-16,共2页Henan Chemical Industry

摘　　要：以庚酸乙酯为原料 ,先与水合肼反应生成庚酰肼 ,庚酰肼在氢氧化钾存在下与二硫化碳经环合、酸化、提纯得到 5 -正己基 - 2 -巯基 - 1,3,4- 口恶二唑。最适宜的工艺条件为n(庚酸乙酯 )∶n(水合肼 ) =1∶1.8,n(庚酰肼 )∶n(二硫化碳 )∶n(氢氧化钾 ) =1∶1.6∶1.1,同时控制二硫化碳加料时间 40min ,并采用石油醚作洗涤剂 ,总收率达到6 0 %。Hexyl-2-mercapto-1,3,4-oxadiazole is obtained via condensation of enanthoyl hydrazine with CS 2 when ethanol is used as solvent.The optimal reaction condition is as follows: the molecular ratio of ethyl oenanthate to hydrazine hydrate is 1∶1.8 , of enanthoyl hydrazine to carbon disulfide to caustic potash is 1∶1.6∶1.1,charge time of CS 2 is 40min ,petroleum ether is used as detergent.The total yield reaches 60%.

关 键 词：5-正已基-2-巯基-1 3 4-恶二唑 庚酸乙酯 庚酰肼 合成 研究 

分 类 号：TQ252.4[化学工程—有机化工]