血小板活化因子受体拮抗剂-BN52021对内毒素引起大鼠急性肺动脉高压影响的观察  

Effect of special platelet-activating factor receptor antagonist(BN 52021) on endotoxin-induced acute pulmonary hypertension in wistar rats

作　　者：汪金锋[1] 江凌[1] 张劲农 

机构地区：[1]武汉华中科技大学同济医学院附属协和医院,430022

出　　处：《实用心脑肺血管病杂志》2002年第5期259-261,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的　探讨特异性血小板活化因子 (PAF)受体拮抗剂 -BN 5 2 0 2 1对内毒素引起的肺动脉高压的影响。　方法　Wistar大鼠静脉注入内毒素引起急性肺动脉高压 ;应用BN 5 2 0 2 1预处理 ;观察BN 5 2 0 2 1对经内毒素处理大鼠的血液动力学、血浆肿瘤坏死因子α(TNF α)、血栓素B2 (TXB2 )及动脉血气变化的影响。　结果　BN5 2 0 2 1可部分抑制内毒素引起的急性肺动脉高压 ;降低血浆TNF α和TXB2 的含量 ;提高动脉血氧分压。　结论　BN 5 2 0 2 1能减轻内毒素引起的肺损伤 ;降低内毒素引起的大鼠肺动脉高压。Objective To study effect of spectial platelet activating factor receptor antagonist(BN 52021) on endotoxin induced acute pulmonary hypertension in wistar rats Methods We intravenous infused endotoxin into wistar rats,to establish acute pulmonary hypertension animal model The rats were received pretreatment of BN 52021 before endotoxin infused We continuously measured pulmonary arterial and aortic arterial pressures;detected in plasma tumor necrosis factor alpha(TNF α) and thromboxane B 2 and arterial blood gas tensions Results BN 52021 attenuated endotoxin induced acute pulmonaxy hypertension,reduced in plasma TNF α and TXB 2 and rose arterial blood oxygen tensions Conclusion BN 52021 could attentuate endotoxin induced acute lung injury and reduce endotoxin induced acute pulmonary hypertension

关 键 词：血小板活化因子受体拮抗剂 BN52021 内毒素 肺动脉高压 血浆肿瘤坏死因子 血栓素B2 

分 类 号：R543.2[医药卫生—心血管疾病]