血清IGF-I和IGFBP_3在检测女童性早熟中的意义  

Significance of Serum IGF-I and IGFBP_3 in Determing Precocious Puberty Girls.

作　　者：崔朝晖[1] 黄建荣[1] 王继东[1] 束琴华[1] 许琦[1] 

机构地区：[1]无锡市儿童医院儿保科,江苏无锡214002

出　　处：《中国儿童保健杂志》2002年第5期297-299,共3页Chinese Journal of Child Health Care

基　　金：江苏省无锡市自然科学基金项目 (K2 0 0 2 0 0 0 3)

摘　　要：【目的】　探讨血清IGF I和IGFBP3 浓度对诊断特发性中枢性性早熟女童以及与单纯乳房早发育女童鉴别的实用价值。　【方法】　对本院就诊的 49例特发性中枢性性早熟女童进行血清IGF -I和IGFBP3 的检测 ,并与同期30例正常青春发育女童 ,55例单纯乳房早发育及 2 0例未发育女童进行比较。　【结果】　分析表明特发性中枢性性早熟女童血清IGF I和IGFBP3 浓度均明显高于单纯性乳房早发育女童及未发育的女童 (P <0 .0 0 1 ) ,而与正常青春发育的女孩无差别。　【结论】　IGF I和IGFBP3 的测定对判断中枢性性早熟以及与单纯乳房早发育女童的鉴别具有重要的实际意义。To study the practical value of serum concentrations of insulin like growth factor I (IGF I) and insulin like growth factor binding protein 3(IGFBP 3)in diagnosing idiopathic central precocious puderty girls and in identifying such girls from those with simple early breast development. Serum IGF I and IGFBP 3 of 49 cases with idiopathic central precocious puberty girls were determined, compared with 30 cases of normal pulerty girl,55 cases of simple early breast development girls and 20 cases of underdeveloped girls. The analysis showed that concentrations of IGF I and IGFBP 3 in girls with idiopathic central precocious puberty were significantly higher than those in simple early breast development girls and underdeveloped girls ( P <0.001). But there was no difference with the normal puberty girls. [Conclusions] Determination of IGF I and IGFBP 3 had practical significance in identifying idiopathic central precocious puberty girls from those of simple early breast development.

关 键 词：血清 IGF-I IGFBP3 检测 女童 性早熟 

分 类 号：R585[医药卫生—内分泌]