系统性红斑狼疮与TFAR19的相关性的研究  

A new gene in systemic lupus erythematosus pathogenesis

作　　者：宋清华[1] 狄春晖[1] 钟英城[1] 陈学荣[1] 李世荫[1] 

机构地区：[1]北京大学第三医院皮肤科,100083

出　　处：《中华风湿病学杂志》2002年第5期328-330,共3页Chinese Journal of Rheumatology

摘　　要：目的　探讨新的凋亡相关基因TFAR19在系统性红斑狼疮 (SLE)发病机制中的作用 ,及其与SLE病情的关系。方法　利用酶联免疫吸附分析 (ELISA)方法检测TFAR19与SLE患者病情的关系。结果　发现活动期SLE患者血清中TFAR19的抗体值高于稳定期和正常对照组 (P≤0 0 5 )。Objective To explore the role of a new apoptosis related gene TFAR 19 in the pathogenesis of systemic lupus erythematosus (SLE) and the relationship between TFAR 19 and SLE.Methods ELISA was used to test if there is relation between TFAR 19 and SLE.Results It was found that in active SLE patients there was higher titer of TFAR 19 antibody than that in stability patients and normal controls.No significant difference was seen between stability patients and normal controls.Conclusion It is first put forward that TFAR 19 may be related with SLE pathogenesis and disease activity.

关 键 词：系统性红斑狼疮 TFAR19 发病机制 相关性研究 

分 类 号：R593.241[医药卫生—内科学]