早产孕妇血清β-hCG水平的临床检测意义  

Study of serum β-hCG level in preterm labor and its significance

作　　者：麻莉[1] 成娅[1] 章容[2] 胡香云[1] 

机构地区：[1]第三军医大学附属新桥医院妇产科,重庆400037 [2]附属西南医院病理研究所,重庆400038

出　　处：《第三军医大学学报》2002年第9期1081-1083,共3页Journal of Third Military Medical University

摘　　要：目的　探讨早产孕妇血清 β hCG水平变化及意义。方法　采用放射免疫分析法检测 3 0例早产患者和 2 43例正常晚期妊娠孕妇的血清 β hCG水平 ,对早产患者的胎盘胎膜组织进行病理学检查并观察其新生儿状况。结果　早产组血清 β hCG水平(2 5 2 4± 13 87) μg /L显著高于对照组 (16 45± 7 3 7) μg/L ,P <0 0 1。早产组中 β hCG水平升高 (≥ 2MOM )的发生率显著高于对照组(10 /3 0vs 7/12 8,P <0 0 0 1。)早产组中 β hCG水平升高者胎盘病变和胎儿预后不良的发生率均高于 β hCG未升高 (<2MOM)者 ,差异有显著性。结论　动态监测整个妊娠期尤其是 3 0周以后的母体血清 β hCG水平 。Objective To study the change of maternal serum β human chorionic gonadotropin (MS β hCG) in preterm labor and its significance. Methods Totally of 30 preterm labor patients were subjected, and 243 normal late-pregnancy women with the same gestational age as the preterm labor women served as controls. Serum MS β hCG level was measured with radioimmunoassy (RIA). Placental tissues of preterm labor women was examined histologically and β hCG content in the tissue was determined with semiquantiative immunohistochemistry. Results Serum MS β hCG was significantly higher in preterm labor than in normal late pregnancy. The incidences of placental pathological changes, low birth weight baby, and asphyxia neonatorum had significant difference between the group of MS β hCG ≥2MOM and the group of MS β hCG<2MOMb ( P <0.01). Immunoreactivity was found in the placental syncytiotrophoblasts of preterm labor women. There was a strongly positive correlation between the MS β hCG and the immunostained positive syncytiotrophoblasts. Conclusion If MS β hCG level is monitored successively during pregnancy, it can be a valuable clinical marker for identifying preterm labor and other complications.

关 键 词：早产 孕妇 血清 Β-HCG 临床检测意义 人绒毛膜促性腺激素-β 

分 类 号：R714.21[医药卫生—妇产科学]