神经垂体内儿茶酚胺能神经与肽能神经相互关系的电镜研究  

ELECTRON MICROSCOPIC STUDY OF THE RELATIONSHIP BETWEEN CATECHOLAMINERGIC AND PEPTIDERGIC NERVE TERMINALS IN THE RAT NEUROHYPOPHYSIS

作　　者：朱长庚[1] 刘庆莹[1] 张喜京[1] 

机构地区：[1]同济医科大学解剖学教研室,武汉430030

出　　处：《解剖学报》1991年第3期242-246,T003,共6页Acta Anatomica Sinica

基　　金：中国科学院科学基金

摘　　要：为了探明神经垂体内神经激素释放的调节机制,本文采用免疫组织化学和化学损毁相结合的方法,在电镜水平分别显示神经垂体内的后叶加压素(VP)能神经和儿茶酚胺(CA)能神经,观察它们的分布和相互关系。结果发现:大鼠神经垂体内不仅有广泛的VP神经终末分布,而且存在着因6-OHDA损毁所致溃变的CA能神经终末。CA能神经终末与垂体细胞和小胶质细胞之间存在着密切关系,甚至可建立突触样连接。CA能终扣与VP能终扣可建立轴-轴突触。在这种情况下,含CA的神经终末为突触前成分,含VP的神经终末为突触后成分。上述结果为神经垂体内神经激素释放的调节机制首次提供了超微结构证据。In order to clarify the regulatory mechanism of the neurohormone releasing in the neurohypophysis, the immunohistochemical and chemical lesion method were combined to demonstrate the vasopressin (VP)-and catecholamine (CA)-containing nerve terminals, and their distribution and relationship were observed under electron microscopic level. The results showed that in the rat neurohypophysis there were not only widely distributed VP nerve terminals, but also there were many 6-OHDA induced degenerated nerve endings. The close relationship even synapse-like contacts existed between the CA-ergic endings and pituicytes as well as microglial cells. It was very interesting that the CA-ergic boutons formed axoaxonic synapses with VP-containing boutons. In this case, the CA-bouton was presynaptic element whereas the VP-bouton served as postsynaptic element. The above mentioned results probably provided ultrastructural evidence for the regulatory mechanism of the neurohormone releasing in the neurohypophysis for the first time.

关 键 词：神经垂体 后叶加压素 儿茶酚胺 

分 类 号：R322.85[医药卫生—人体解剖和组织胚胎学]