分子内桥连有机钴配合物的合成及热稳定性研究  

Synthesis and Thermostability Study Intramolecularly Bridged Alkyl Cobaloximes Complex

作　　者：姚开安[1] 蒋玉萍[1] 周志萍[1] 陈慧兰[1] 

机构地区：[1]南京大学化学系

出　　处：《无机化学学报》2002年第11期1165-1168,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.20071017);博士点基金资助(No.2000028401)。

摘　　要：The intramolecularly bridged alkyl cobaltic complexes are one of important coenzyme B12 model coplexes. In this paper, study on the thermolytic reaction of aqua(3 bromopropyl)cobaloximes in solution revealed that a new intramolecularly bridged alkyl cobaloximes complex was formed and the reaction is influenced by tempertature and solvent. Adding cyclodxtrin has no obvious effect to the rate of the reaction, but various products with different axial bases were obtained. The intramolecularly bridged alkyl cobaloxime complex (bromo(O trimethylene dimethy lglyoxime)(dimethylglyoximate)cobalt?) was characterized by EA and ESI MS. Thermogravimetric analysis of this complex found that a carbon radical that from homolysis of the Co C bond is retained in the proximity of CoⅡ complex, which is very similar to the behavior of coenzyme B12.The intramolecularly bridged alkyl cobaltic complexes are one of important coenzyme B-12 model coplexes. In this paper, study on the thermolytic reaction of aqua (3-bromopropyl) cobaloximes in solution revealed that a new intramolecularly bridged alkyl cobaloximes complex was formed and the reaction is influenced by tempertature and solvent. Adding cyclodxtrin has no obvious effect to the rate of the reaction, but various products with different axial bases were obtained. The intramolecularly bridged alkyl cobaloxime complex (bromo (0-trimethylene-dimethyl-glyoxime) (dimethylglyoximate) cobalt (M)) was characterized by EA and ESI-MS. Thermogravimetric analysis of this complex found that a carbon radical that from homolysis of the Co-C bond is retained in the proximity of Co-II-complex, which is very similar to the behavior of coenzyme B-12.

关 键 词：合成 热稳定性 辅酶B12 分子内桥连有机钴配合物 紫外可见光谱 固体热重分析 模型化合物 

分 类 号：Q552[生物学—生物化学] O614.812[理学—无机化学]