前列腺素E_2与雌二醇联合应用对动脉粥样硬化的影响和机理探讨  

Effects and Mechanism of Prostaglandin E_2 Combined with Estradiol on Experimental Atherosclerosis

作　　者：邱近明[1] 高玉霞[1] 范英昌[1] 赵晖[1] 王晓燕[1] 

机构地区：[1]天津医学院病理教研室

出　　处：《天津医药》1991年第7期387-390,F003,共5页Tianjin Medical Journal

基　　金：天津市四病防治中心资助课题

摘　　要：在本室以往研究的基础上,利用同位素技术、血清过氧化脂质(LPO)、血小板聚集性和血脂测定以及形态学和超微结构等方法,综合观察了大剂量前列腺素 E_2(PGE_2)和雌二醇联合应用对实验性动脉粥样硬化(AS)的影响,结果多种指标显示联合用药比单纯 PGE_2具有更明显的抑制 AS 的协同作用。文中根据各种检测指标的变化就其作用机理进行了讨论。The effects of PGE_2 combined with estradiol on experimental atherosclerosiswere studied by biochemical techniques of isotope,determination of lipid peroxide andserum lipid,platelet aggregation,and morphologic ultrastructural observations.Theresults showed that large dose of PGE_2 inhibited rabbit atherosclerosis and the com-bined treatment group of PGE_2 with estradiol was synergistic in the inhibition.The mechanisms might be related to the synergistic inhibition of above drugs on en-dothelial permeability,platelet aggregation,smooth muscle cell proliferation andperoxidation.

关 键 词：前列腺素E2 雌二醇 动脉粥样硬化 

分 类 号：R969.4[医药卫生—药理学]