结核性与恶性胸腔积液CRP与LDH的临床研究  

Clinical Research of CRP and LDH in diagnosis of Tuberculous effusion and malignant effusion

作　　者：胡涛[1] 刘跃建[1] 韩旭[2] 

机构地区：[1]四川省人民医院呼吸科,成都610072 [2]四川石油总医院,610212

出　　处：《中原医刊》2002年第11期1-2,共2页Central Plains Medical Journal

摘　　要：目的 :探讨胸水C反应蛋白 (CRP)、乳酸脱氢酶 (LDH )测定及胸水 /血CRP、胸水 /血LDH ,对鉴别结核性和恶性胸腔积液的临床意义。方法 :采用速率散射比浊法用BeckmanArrayProteinSystem同时测定 2 4例结核性和 13例恶性胸腔积液病人的血和胸水CRP浓度。同时用Beckman生化分析仪测定 ,37例病人的血及胸水乳酸脱氢酶 (LDH )水平。结果 :结核性胸液CRP水平明显高于恶性胸液CRP值 (分别为 4 5 1± 4 2 6mg/dl与 0 79± 0 5 9mg/dl,P <0 0 0 5 ) ,结核性及恶性胸液胸水 /血CRP浓度比值比较无显著差异 (P >0 0 5 ) ,结核性胸液及恶性胸液LDH及胸水 /血LDH比值比较均无显著差异 (P >0 0 0 5 )。结论 :CRP浓度测定是临床上常用的快速、实用、经济的检测方法 。Purpose: The aims of the study were to asses whether C-reactive protein (CRP)is a sensitive maker for distinguishing tuberculous effusions and malignant effusions.Method: Pleural fluid and serum CRP levels were obtained in 37 patients, with pleural effusions, using an rate nephelometry method (Beckman array Protein System Analyzers).At the same time, pleural fluid and serum LDH levels were obtained using Beckman Analyzers. Results: According to the Criteria used 24 patients were included in tuberculous effusions and 13 patients in malignant effusions. Pleural fluid CRP levels were significantly higher in tuberculous effusion ( P<0.05,4.51±4.26mg/dl,0.79 ±0.59mg/dl respectively). Also, the rations of pleural fluid to serum were similar in tuberculous and malignant effusion. Pleural fluid and serum LDH levels, the ratios of pleural fluid to serum LDH were similar in this two kinds of effusions. In the differential diagnosis of pleural effusions.higher:CRP levels may prove to be a rapid practical and economical method of differentiating tuberculous effusions from malignant effusions.

关 键 词：C反应蛋白 乳酸脱氢酶 结核性胸腔积液 恶性胸腔积液 

分 类 号：R52[医药卫生—内科学]