腹膜透析及血液透析对尿毒症患者血脂的影响  

The Effects of Peritoneal Dialysis and Hemodialysis on Blood Lipid in Patients With Uremia

作　　者：刘映红[1] 刘虹[1] 段绍斌[1] 李军[1] 朱建玲[1] 

机构地区：[1]中南大学湘雅二医院肾病内科,湖南长沙410011

出　　处：《中国医师杂志》2002年第9期936-938,共3页Journal of Chinese Physician

摘　　要：目的　观察尿毒症患者采用血透或腹透后血脂水平的变化。方法　所有患者均在治疗前及治疗后6个月测定其血胆固醇 (CHO)、甘油三脂 (TG)、低密度脂蛋白 (LDL)、高密度脂蛋白 (HDL)、载脂蛋白A1(ApoA1) ,载脂蛋白B(ApoB)及LP(a)。结果　尿毒症患者CHO ,TG ,LDL ,ApoB显著上升 ,而HDL和ApoA1明显下降 ,尤其腹透后明显 ,而血液透析与非透析组治疗前后无明显差别。结论　尿毒症患者脂质代谢已发生紊乱 ,腹膜透析后会进一步加重脂质代谢紊乱 。Objective The aim of the study was to observe the change of blood lipid in uremic patients after hemodialysis or peritoneal dialysis. Methods Sera cholesterol(CH), triglyceride(TG), LDL, HDL, ApoA1, ApoB and LP(a) were measured in all patients who were dialystic treated before and after six months.Results CH, TG, LDL, HDL, ApoA1 and ApoB were significant increased in patients with uremia,but HDL, ApoA1 was significant decreased,they were apparent especially after peritoneal dialysis .However,the blood lipid levels of patients with hemodialysis or non-dialysis did not significant difference before or after treatment. Conclusions The metabolism of blood lipid in uremic patients have been changed. The disturbance will aggravate after peritoneal dialysis.We consider that therapy of reducing blood lipid is necessary in the both patients with dialysis and non- diaylsis for the uremic patients.

关 键 词：尿毒症 脂质 载脂蛋白 腹膜透析 血液透析 

分 类 号：R459.5[医药卫生—治疗学]