新生儿接种10ug3针乙型肝炎血源疫苗5年内的...  

A FIVE YEARS FOLLOWING UP STUDY OF INFANTS IMMUNIZED WITH LOW DOSES OF PLASMA-DERIVED HEPATITIS B VACCINE

作　　者：沙庆洪[1] 刘玉霞[1] 刘家璧[1] 黄祖星[1] 吴静仪 何少兼 李杰[1] 徐志一[2] 

机构地区：[1]广东省卫生防疫站 [2]上海医科大学流行病学教研室

出　　处：《病毒学报》1991年第A12期81-84,共4页Chinese Journal of Virology

摘　　要：1986～1958年,对广东3个城市1～5岁儿童乙型肝炎病毒(HBV)感染做横断面调查的基础上,给新生儿普种乙型肝炎血源疫苗。出生后24小时内接种1针,1、6个月接种第、3针,每针10μg,共接种1万余名。免疫后抽查HBsAg阳性母亲新生儿血380人份,HBsAg阴性母亲新生儿血1466人份。同时采集同期出生的未免疫的新生儿血116份作为内对照。以放射免疫法(RIA)检测HBV指在。结果,新生儿免疫后1～5年,标化抗-HBs阳转率为67.3％～79.1％。免疫后1～5年HBsAg阳性率与免前HBsAg阳性率比较,其保护率为65.8％～92.1％;与平行内对照的HBsAg阳性率比较,保护率为58.6％～88.1％。且发现HBsAg阳性母亲的新生儿,随免疫年限延长,HBsAg阳性率有降低趋向。In three cities of Guangdong province we have studied a low dosage scheme HBV vaccine immunization for all infants from 1986-1988.A total of 10, 000 infants received three doses of 10μg/ml plasma-derived HB vaccine produced by Beijing National Institute of Biological Products. The vaccine was gived intramascularly by a 0-1-6 month schaduele. A total of 330 infants born to HBsAg positive mothers and 1,466 born to HBsAg negative mothers were tested in five successive years for HBsAg and anti-HBs.The result showed the anti-HBs remained high with a positive rate 72.8% by the fifth year, as compared with that 79.1% in the first year after vaccination. The HBsAg positive rate in immunized children dropped from 16.7% among the same age group children before immunization to 3.25% by the fifth year. The protective rate is 80.5%.

关 键 词：乙肝疫苗 免疫结果 新生儿 血源 

分 类 号：R512.620.3[医药卫生—内科学]