乙型肝炎血源疫苗不同免疫剂量阻断新生儿母婴传播的效果观察  

PREVENTION OF PERINATAL TRANSMISSION OF HEPATITIS B VIRUS(HBV) BY USING VARIOUS DOSES OF PLASMA-DERIVED HEPATITIS B VACCINE

作　　者：沙庆洪[1] 刘玉霞[1] 刘家壁 徐勇[1] 荆庆 彦天强 徐志一[4] 刘崇柏[5] 

机构地区：[1]广东省卫生防疫站 [2]河南省开封市肝病研究所 [3]湖南省湘潭市卫生防疫站 [4]上海医科大学流行病教研室 [5]中国预防医学科学院病毒学研究所

出　　处：《病毒学报》1991年第A12期56-60,共5页Chinese Journal of Virology

摘　　要：用乙型肝炎血源疫苗,按0、1、6程序,分5种不同剂量免疫HBsAg和HBeAg均阳性(双阳性)母亲和仅HBsAg阳性母亲的新生儿,井于首针后8～12个月采血,用放射免疫(RIA)法检测他们的HBsAg和抗-HBs、抗-HBc,以比较不同剂量乙肝疫苗阻断母婴传播的效果。结果,10μg×3组对双阳性和仅HBsAg阳性母亲的新生儿的保护率,分别是42.9％和53.5％;20μ×3组为67.4％和69.7％;30μg、10μg、10μg组为75.6％和79.8％,30.20、20μg(含30、30、10μg)组为80.2％和81.5％;30μg×3组为82.3％和83.7％。随疫苗剂量增加保护率逐渐增加,抗-HBs阳转率也是如此。The immunogenicity and efficacy of plasma derived HB vaccine in 1,070 neonates born to HBsAg carrier mothers, receiving various doses of vaccine by the month 0, 1, 6 schedule have been investigated.The blood samples of all vaccinees was taken at 8-12 months of age and tested by RIA kits for HBsAg, anti-HBs and anti-HBc.The results showed that, the antigenicity and protection of HBsAg antigenemia increased proportionally with increasing vaccine dosages used. The anti-HBs coversion and protective rates were 51.6% and 42.9% respectively after completion of 3 doses of long vaccine immunization for babies of both HBsAg and HBeAg-positive mothers. Different dosage schedules had no statistical significance in antigeni-city or protective rate when 30μg dose of vaccine was used for the first injection. The data indicate that ( 1 ) 10μg vaccine is inefficient for prevention of perinatal HBV infection) ( 2 ) the higher the dose of vaccine used in the first injection, the better are the results for interuption of perinatal HBV transmission.

关 键 词：乙肝疫苗 母婴传播 保护率 血源 

分 类 号：R512.620.3[医药卫生—内科学]