急性创伤对免疫器官组织细胞内cAMP、cGMP及DNA水平的影响  

Effect of Acute Trauma on cAMP, cGMP and DNA Levels in the Immune Cells, Tissues, or Organs

作　　者：韩玉玺[1] 胡南方[1] 白祥军[1] 李美颖[2] 赖世英[2] 魏文华[2] 田大武 

机构地区：[1]同济医科大学附属同济医院急诊外科 [2]同济医科大学核医学科

出　　处：《同济医科大学学报》1991年第A12期24-26,共3页Acta Universitatis Medicinae Tongji

基　　金：国家自然科学基金

摘　　要：本试验以杂种狗为对象,观察了急性创伤后免疫器官组织细胞内cAMP、cGMP及DNA水平的变化。发现创伤早期骨髓中cAMP及cAMP/cGMP值分别下降31％和34.1％(P<0.05)。从而有利于骨髓细胞的生长与分裂,加速粒细胞的释放。淋巴结、血浆和白细胞内环核苷酸水平在伤后早期亦有相应改变,cGMP及DNP水平保持稳定,说明在创伤早期机体主要免疫器官无明显生物合成。The effect of acute trauma on cAMP, cGMP and DNA levels in the immune cells, tissues, or organs (heterogeneous dogs) was studied,The results indicate that the content of cAMP and the cAMP/cGMP ratio in bone marrow decreased by 31.0% and 34.1 %, respectively, (P<0.05) in the early stage of trauma, which promoted the growth and mitosis of bone marrow cells and contributed to the release of the granulocytes, thereby leading to the changes in white blood cells. The corresponding changes in the cyclic nucleotides in lymph glands, plasma and white blood cells during the early stage of trauma wer ealso observed.

关 键 词：创伤 环腺苷酸 CGMP 脱氧核糖核酸 

分 类 号：R641[医药卫生—外科学]