中脑导水管周围灰质内催产素在电针镇痛中作用机制的研究  

THE EFFECT OF OXYTOCIN IN PERIAQUEDUCTAI GRAY ON ELECTROACUPUNCTURE ANALGESIA OF RATS

作　　者：刘文彦[1] 张艳霞[1] 刘玉红[1] 葛凤[1] 冀强[1] 白波[1] 

机构地区：[1]济宁医学院生理学教研室

出　　处：《济宁医学院学报》2002年第3期8-10,共3页Journal of Jining Medical University

基　　金：山东省自然科学基金资助课题 (No.Q98C0 112 4)

摘　　要：目的　探讨中脑导水管周围灰质 (PAG)内催产素 (OT)与内源性强啡肽在电针镇痛中的关系。方法　以钾离子透入法引起大鼠甩尾反应的电流强度 (mA)为痛行为反应的指标 ,观察向PAG内注入OT和抗强啡肽A1- 13血清 ,对动物电针镇痛效应的影响。结果　PAG内注入OT后 ,大鼠电针镇痛的效应明显升高 ;而注入抗强啡肽血清后 ,对OT电针镇痛的效应无显著影响。结论　PAG内OT在电针镇痛中发挥着重要的作用 。Objective To study the effect of oxytocin(OT) on electroacupuncture analgesia in periaqueductal gray(PAG) and its relation to endogenous dynorphin A 1-13 .Methods Potassium iontophoresis induced tail-flick was used to measure the pain threshold.Results OT administration induced an enhancement of electroacupuncture analgesia.Furthermore,pre-injection of ADYNS in PAG could not weaken analgesia effect of OT.Conclusion These data suggest the enhancement of electroacupuncture analgesia by OT is not dependent upon the dynorphin A 1-13 in PAG.

关 键 词：催产素 抗强啡肽血清 导水管周围灰质 电针镇痛 

分 类 号：R338.8[医药卫生—人体生理学]