Ultrastructural Study of Moniliformin Induced Lesions of Myocardium in Rats and Mice  

作　　者：ZhaoDeyu FengQl 等 

机构地区：[1]InstituteofMateriaMedica.ChineseAcademyofMedicalSciences,IXianNongTanStreet,Beijing,100050China [2]Insti

出　　处：《Biomedical and Environmental Sciences》1993年第1期37-44,共8页生物医学与环境科学（英文版）

摘　　要：Effects of moniliformin on the ultrastructure of the myocardium of mice and rats were studies. Mice were given moniliformin orally at a dose of 29.46 mg-kg the LD50. One h after dosing, lesions of the mitochondria of the myocardial cells were found which became more severe in 2 and 3 h. Ultrastructural lesions were also observed in the myofibrils and sarcolemma. Rats were given moniliformin orally at the dosage of 6 mg-kg-1 once daily for 56 d. Lesions of mitochondria and myofibrils were relatively mild. In the myocardiac specimens taken from the 21d post-toxin administration, lesions of the sarcolemma became more obvious. These moniliformin-induced lesions were simillar to the ultrastructural changes in the myocardium of patients with Keshan disease. Our findings indicate that there may be a close and important relationship between moniliformin intoxication and Keshan disease.Effects of moniliformin on the ultrastructure of the myocardium of mice and rats were studies. Mice were given moniliformin orally at a dose of 29.46 mg-kg the LD50. One h after dosing, lesions of the mitochondria of the myocardial cells were found which became more severe in 2 and 3 h. Ultrastructural lesions were also observed in the myofibrils and sarcolemma. Rats were given moniliformin orally at the dosage of 6 mg-kg-1 once daily for 56 d. Lesions of mitochondria and myofibrils were relatively mild. In the myocardiac specimens taken from the 21d post-toxin administration, lesions of the sarcolemma became more obvious. These moniliformin-induced lesions were simillar to the ultrastructural changes in the myocardium of patients with Keshan disease. Our findings indicate that there may be a close and important relationship between moniliformin intoxication and Keshan disease.

分 类 号：R996.2[医药卫生—毒理学] R992[医药卫生—药学]