Acetylcholinesterase Characteristics of Termite Queen Exposed to Anticholinesterase Compounds  

作　　者：SHELLEY BHATTACHARYA PROBODH GHOSH SHAMPA GHOSH NINA GHOSH B.BHATTACHARYA P.HALDER 

机构地区：[1]Environmental Toxicology Laboratory,Department of Zoology,Visva-Bharati University,Santiniketan-731235,India

出　　处：《Biomedical and Environmental Sciences》1992年第2期178-183,共6页生物医学与环境科学(英文版)

基　　金：PG and SG are grateful to the Council of Scientific and Industrial Research,New Delhi;PH to the Department of Science and Technology,New Delhi for financial support.

摘　　要：A regional profile of AChE activity was noted in the Indian termite queen Odontotermes redemanni with the head recording the higher and body the lower range of activity.The enzyme characteristics such as substrate and temperature optima were more or less similar while pH requirement for optimum AChE activity varied from 7.0 to 7.6 In vitro inhibition of head and body AChE was studied using pure and commercial anticholinesterase compounds.Interestingly,the commercial formulations like Metacid-50 and Carbaryl are potent enough at 1×10^(-8)M to produce 50%in vitro inhibition of AChE of head and body regions within 15 min of preincubation.A 20 min of preincubation(t0.5)was necessary to record 50%in vitro inhibition of AChE with known and pure anticholinesterase compounds such as DFP(3.5×10^(-10)M)and physostigmine(3.6×10^(-10)M).It is surmised that(a)the response of the head and body AChE to the commercial formulations of the insecticides may be used as a reliable and sensitive bioindicator of pesticidal contamination of the terrestrial environment and(b)termite control may be successfully done with the application of organophosphate or carbamate compounds.

分 类 号：R979.8[医药卫生—药品]