咪唑安定对重度OSAS术后带气管插管患者的镇静研究  

Study of sedation with midazolam in postoperative and tracheal intubated patients with OSAS

作　　者：侯静[1] 葛庆岗[1] 何伟[1] 周华[1] 李彤[1] 许元[1] 

机构地区：[1]首都医科大学附属北京同仁医院外科ICU,100730

出　　处：《耳鼻咽喉（头颈外科）》2002年第5期286-288,共3页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：目的 :探讨咪唑安定对重度阻塞性睡眠呼吸暂停综合征 (OSAS)患者术后带气管插管期间的镇静效果及其应用安全性。方法 :重度 OSAS患者 32例 ,全部行 UPPP手术 ,术后带经鼻气管插管 ,给予咪唑安定镇静 ,对用药前、用药期间、拔除气管插管后血压、心率、呼吸频率、Sp O2 及血气分析监测。结果 :使用咪唑安定 1小时以后至拔管 ,MAP、RR均明显低于使用前 (P <0 .0 5 ) ,使用咪唑安定 1小时、6小时 Sp O2 显著提高 (P <0 .0 5 )、p H调整至正常范围 ,而 PO2 和PCO2 无明显变化。结论 :重度 OSAS患者术后带气管插管期间使用咪唑安定作为镇静剂安全有效。Objective: To determine the effect of sedation of midazolam in postoperative patients with severe obstructive sleep apnea syndrome (OSAS)in duration of endotracheal intubation.Methods:All 32 patients with severe OSAS were treated by surgery uvulopalatopharyngoplasty (UPPP).Nasotracheal intubation was performed and patients were treated with midazolam postoperatively.The blood pressure,heart rate ,respiration rate,SpO 2 and blood gas were monitored before,during the treatment with midazolam and after tracheal extubation.Results:During 1 hour after receiving midazolam to tracheal extubation,the mean arterial pressure(MAP),RR decreased significantly(P<0 05).SpO 2 increased greatly at 1 hour,6 hour after treatment with midazolam separately (P<0 05).The pH of blood was back to normal.No significant differences in PO 2 and PCO 2 were observed.Conclusion:As a calmative,midazolam is safe and effective to postoperative patients with severe OSAS in duration of endotracheal intubation.

关 键 词：咪唑安定 带气管插管 镇静 睡眠无呼吸综合征 

分 类 号：R766.9[医药卫生—耳鼻咽喉科]