羟甲烟胺对环孢菌素A药代动力学参数的影响  

Influence of Nicotinylmethylamide on the Pharmacokinetics Parameters of Cyclosporin A

作　　者：李芹[1] 梁永广[1] 赵秀杰[1] 赵焰[2] 郭瑞臣[3] 

机构地区：[1]山东省聊城市人民医院药学部,聊城252000 [2]山东大学药学院药剂实验室,济南250012 [3]山东大学齐鲁医院临床药理研究所,济南250012

出　　处：《中国临床药理学杂志》2002年第5期371-373,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的:研究羟甲烟胺对环孢菌素A药物动力学参数的影响。方法:采用荧光偏振免疫分析法（FPIA）测定18名健康志愿者单服环孢菌素及同服羟甲烟胺后环孢菌素的血药浓度,用3P97程序分析处理数据,比较两组药动学参数的变化。结果:单服环孢菌素及同服羟甲烟胺后环孢菌素的Cmax和AUC（0-∞）有极显著性差异（P<0.001）,而t1/2（β）、tmax无显著性差异（P>0.05）。结论:羟甲烟胺可促进环孢菌素的吸收,提高环孢菌素的峰浓度及药时曲线下面积,但不影响环孢菌素的代谢。OBJECTIVE: To study the influence of Nicotinylmethylamide (BILOCID) on the pharmacokinetics parameters of Cyclosporin A (CsA). METHODS: Whole blood CsA concentrations were measured by a fluorescence polarization immunoassay (FPIA) in 18 healthy volunteers administrated single CsA or co-administrated bil ocid. The data of time-blood concentrations of CsA were analyzed by 3P97 Practical Pharmacokinetics Program and the analysis of variance and two one-sided t-test were used to compare the main pharmacokinetics parameters of CsA in the two administrations. RESULTS: The results implied that Cmax and AUC(0-∞) ofCsA had statistically significant difference between the single CsA group and co-administration of bil ocid group (P<0.001), while t1/2(β) and tmax of CsA had no statistically significant difference between the two groups (P>0.05). CONCLUSION: bil ocid could improve the absorption of CsA and increase the Cmax and AUC of CsA, but had no influence on the metabolism of CsA.

关 键 词：羟甲烟胺 环孢菌素A 药代动力学 参数 

分 类 号：R979.5[医药卫生—药品]