甲硝唑生物粘附微球的粘附性能研究  

Mucoadhesive Property of Bioadhesive Microspheres of Metronidazole

作　　者：黄静琳[1] 陆锦芳[1] 

机构地区：[1]复旦大学药学院药剂学教研室,上海200032

出　　处：《中国医药工业杂志》2002年第9期439-441,共3页Chinese Journal of Pharmaceuticals

摘　　要：分别考察了甲硝唑生物粘附微球在离体和在体鼠胃粘膜上的滞留率 ,以评价微球的生物粘附性。建立了 RP-HPL C- UV法 ,测定大鼠胃组织匀浆中的甲硝唑浓度。分别口服本微球和甲硝唑 0 .5 % MC混悬剂 ,2 .5 h后大鼠胃内的甲硝唑滞留率分别为 2 1.34%± 7.6 5 %和 0 .6 9%± 0 .0 7%。The bioadhesive property of metronidazole ethyl cellulose carbomer microspheres was evaluated by the retention percentage of microspheres on mouce gastric mucin in vitro and rat gastric mucin in vivo. A RP HPLC method with ultraviolet detection has been developed for determination of metronidazole in rat stomach 2.5 h after the administration of the microspheres to conscious rat, the percentage of metronidazole remained in the stomach was 21.34%±7.65%. However, the percentage of metronidazole of 0.5%MC suspension remained in the stomach was only 0.69%±0.07%.

关 键 词：甲硝唑 生物粘附微球 粘附性能 高效液相色谱法 抗幽门螺杆菌 

分 类 号：R975.6[医药卫生—药品] R944.9[医药卫生—药学]