+G_z重复暴露对大鼠血小板粘附、聚集和血流变的影响  

Effect of repeated +G_z exposures on platelet adhesiveness, aggregation and hemorheology in rats

作　　者：沙建慧[1] 刘英华[2] 姚萍[1] 朱洪鸣 梁平 刘志洋[1] 李云义[1] 

机构地区：[1]第四军医大学吉林军医学院生理教研室,吉林132013 [2]吉林市中心医院检验科,132010 [3]吉林市医院免疫实验室,132010

出　　处：《中华航空航天医学杂志》2002年第3期156-158,共3页Chinese Journal of Aerospace Medicine

摘　　要：目的　探讨 +Gz 重复暴露后 ,大鼠血小板计数 (PL T)、粘附试验 (PAd T)、聚集试验(PAg T)和血液流变学的变化。　方法　利用动物离心机 ,将大鼠分别重复暴露 +10 Gz 2 0 s、+10 Gz40 s,共作用 4次 ,两次之间间歇 5 min。观察 +Gz暴露后 ,PL T、PAd T、PAg T和血液流变学的变化。　结果　 +10 Gz 40 s组与对照组相比 ,PL T、PAd T和 PAg T都明显增加 (P<0 .0 5或 P<0 .0 1) ;全血粘度 (ηb)、全血还原粘度 (ηrd)和红细胞聚集指数 (EAI)亦增加 ,差异均有显著性意义 (P<0 .0 5 )。+10 Gz 2 0 s与对照组相比 ,各参数无明显变化。　结论　 +10 Gz 40 s重复暴露可引起血小板粘附、聚集功能增强和血液流变学的改变 ,而 2 0 s的 10 GzObjective To investigate the changes of platelet count (PLT), platelet adhesiveness(PAdT), platelet aggregation (PAgT) and hemorheology in rats after repeated +G z exposures. Methods Twenty four SD rats served as subjects. They were randomly divided into control group and 2 experimental groups, which underwent repeated (4 times)+10 G z 20 s and +10 G z 40 s respectively with 5 min interval in between 2 exposures. PLT, PAdT, PAgT and hemorheology were measured after repeated +G z exposures. Results Compared with those of control group the PLT, PAdT and PAgT of +10 G z 40 s group were significantly higher (P<0.05 or P<0.01); and the hemorheology indexes also showed significant changes, while in +10 G z 20 s group the changes of these indexes were non-significant. Conclusion The repeated +10 G z 40 s exposures can induce changes of PLT, PAdT, PAgT and hemorheological indexes in rats, while repeated +10 G z 20 s exposures can't.

关 键 词：+GZ重复暴露 加速度 血小板粘附 血小板聚集 血液流变学 脑缺血 

分 类 号：R82[医药卫生—临床医学]