模拟不同高度对清醒兔奥狄氏括约肌运动功能的影响  

Effect of various simulated altitudes on sphincter of Oddi motility in conscious rabbits

作　　者：杨春敏[1] 张映辉[1] 靳京生[1] 毛高平[1] 张秀荣[1] 

机构地区：[1]空军总医院消化科,北京100036

出　　处：《中华航空航天医学杂志》2002年第3期169-171,共3页Chinese Journal of Aerospace Medicine

摘　　要：目的　在低压舱中模拟不同高度 ,观察兔奥狄氏括约肌动力的变化。　方法　建立兔慢性奥狄氏括约肌测压模型 ,应用低顺应性毛细管水灌注腔内测压系统记录清醒兔奥狄氏括约肌收缩活动。在基础状态 (地面水平 )、模拟升至 30 0 0 m和 5 0 0 0 m高度分别记录奥狄氏括约肌压力30 min。　结果　 1在 5 0 0 0 m高度 ,兔奥狄氏括约肌基础压力明显比基础状态时降低 (P<0 .0 1) ;2在 5 0 0 0 m高度 ,兔奥狄氏括约肌时相收缩的频率、振幅和动力指数明显降低 (P<0 .0 1) ,时相收缩的周期时间无明显变化 ;330 0 0 m高度对兔奥狄氏括约肌动力无显著影响。　结论　急性暴露于5 0 0 0Objective To observe changes of sphincter of Oddi (SO) motility in conscious rabbits at 3 000 m and 5 000 m altitudes in hypobaric chamber. Methods The animal models (n=8) for chronically measuring SO pressures were established, and SO contractile activities were recorded for 30 min at ground level, 3 000 m and 5 000 m altitude respectively, using low compliance capillary water perfusion manometric system. Results ① SO basal pressure during 5 000 m exposure was significantly lower than that at ground level (P<0.01). ② Amplitude, frequency and motility index of phasic contractions during 5 000 m exposure were significantly lower than that at ground level (P<0.01), whereas the duration of contraction did not change obviously. ③ SO motility was not changed obviously during 3 000 m exposure. Conclusion Acute exposure to hypobaric hypoxia up to 5 000 m can inhibit SO motility in rabbits.

关 键 词：低氧 兔 奥狄氏括约肌 运动功能 

分 类 号：R852[医药卫生—航空、航天与航海医学]