应用几丁聚糖治疗急性腹膜炎和预防肠粘连的实验研究  

An experimental study of chitosan in the treatment and prevention of adhesions in acute peritonitis.

作　　者：窦昭峰[1] 王建东[1] 

机构地区：[1]山东省青岛市人民医院普外科,266001

出　　处：《中华急诊医学杂志》2002年第4期239-241,共3页Chinese Journal of Emergency Medicine

摘　　要：目的　研究几丁聚糖对大鼠急性腹膜炎的治疗和术后肠粘连的预防作用。方法　 4个月龄大鼠 2 0 0只制成急性腹膜炎和肠粘连动物模型。用 1 %的几丁聚糖作腹腔灌注 ,以生理盐水、 1 %醋酸和甲硝唑分别作对照 ,观察大鼠的死亡率、两周后存活动物的肠粘连程度和血清可溶性白细胞介素 - 2受体水平。结果　几丁聚糖显著降低大鼠的死亡率和粘连等级 (P <0 0 5)。在不同时间血清可溶性白细胞介素 - 2受体显著低于各对照组 (P <0 0 5)。结论　 1Objective To study the effects of chitosan on the treatment and prevention of post operative intestinal adhesion in rats with acute peritonitis.Methods Two hundred 4-month-old wistar rats were made to develop intestinal adhesion and acute peritonitis.1% chitosan was given intraperitoneally to rats in treatment group,1% acetic acid in control group,then the mortality and the grade of adhesion in animals which survived after two weeks and serum level of receptor of interleukin-2 were assessed.Results The treatment group had a lower mortality and lower grades of adhesion than the control group.In the treatment group receptor of interleukin-2 in serum was lower than the control group at every time.Conclusion 1% chitosan may have a role in treating peritonitis and preventing postoperative intestinal adhesion. [

关 键 词：急性腹膜炎 几丁聚糖 肠粘连 治疗 预防 动物模型 

分 类 号：R656.1[医药卫生—急诊医学]