体液免疫抗白念珠菌感染的研究  

RESEARCH OF HUMORAL IMMUNITY AGAINST CANDIDA ALBICANS INFECTION

作　　者：傅颖媛[1] 莫冰[1] 曾小平[1] 况南珍[1] 张志[1] 

机构地区：[1]江西医学院免疫学教研室,南昌330006

出　　处：《微生物学通报》2002年第5期57-60,共4页Microbiology China

基　　金：江西省自然科学基金资助项目 (No 9740 2 8);江西省科学技术厅资助项目 (E970 1 0 2 )

摘　　要：探讨抗白念珠菌IgY及其免疫血清对多种动物模型感染白念珠菌的保护作用。制备烧伤继发感染白念珠菌大鼠、白念珠菌性阴道炎小鼠及免疫功能低下小鼠多种动物感染模型 ,分别应用抗白念珠菌IgY、鼠免疫血清和生理盐水对照 ,观察比较各自的作用。抗白念珠菌IgY对烧伤继发感染白念珠菌大鼠及白念珠菌性阴道炎小鼠均有明显的保护作用 ;鼠免疫血清则对阻止远程靶器官的白念珠菌扩散有较好的作用。体液免疫成份抗白念珠菌IgY及其免疫血清对烧伤继发感染白念珠菌大鼠、白念珠菌性阴道炎小鼠及免疫功能低下小鼠均有良好的保护作用。To study the role of anti- C. albicans IgY and serum in protection of C. albicans infection of several animal models. To develop three animal models of C. albicans infection: a burned rat model of C. albicans infection, a mouse model of vaginal candiasis and a immunosuppression mouse model of C. albicans infection. And we compared the contribution of anti- C. albicans IgY and serum to the clearance of the C. albicans in three animal models of C. albicans infection. Anti- C. albicans IgY can protect against C. albicans infection in a burned rat model of C. albicans infection and a mouse model of vaginal candidiasis. The serum can effectively protect the mice from disseminated candidiasis in a immunosuppression mouse model. Humoral immunity component involving anti- C. albicans IgY and serum protect against C. albicans infection in a burned rat model of C. albicans infection ,a mouse model of vaginal candidiasis and a immunosuppression mouse model of C. albicans infection.

关 键 词：体液免疫 抗白念珠菌感染 烧伤继发感染 

分 类 号：R519[医药卫生—内科学]