米帕林对硬膜外移植自体髓核大鼠马尾电生理损害的保护作用  

Injecting mepacrine to protect rats with autologous nucleus pulposus transplanted into cavum epidurale from electrophysiologic impairment of cauda equina

作　　者：贺石生[1] 侯铁胜[1] 崔毅[2] 王建文[3] 夏金辉[3] 王劼[4] 

机构地区：[1]第二军医大学附属长海医院骨科,200433 [2]第二军医大学附属长海医院神经内科,200433 [3]第二军医大学生理教研室,200433 [4]复旦大学医学院解剖教研室

出　　处：《中国行为医学科学》2002年第5期485-487,共3页Chinese Journal of Behavioral Medical Science

基　　金：上海市科委学科带头人基金资助项目 (97XD1 4 0 1 5)

摘　　要：目的　探讨磷脂酶A2在腰椎间盘突出症相关腰腿痛发病中的作用。方法　通过硬膜外置管的方法给硬膜外移植自体髓核的大鼠注射磷脂酶A2抑制剂米帕林 ,然后对马尾电生理的重要参数进行了测定。结果　大鼠硬膜外移植自体髓核后能使马尾的电生理功能产生明显的损害作用 ,在注射米帕林后 ,大鼠马尾的电生理损害明显减轻 ,与髓核移植组相比较 ,统计学上差别显著 (P <0 .0 5 )。结论　磷脂酶A2在腰椎间盘突出症相关腰腿痛的发病中起到重要的作用 。Objective To elucidate the role of phospholipase A2 in the pathomchanism of low back pain and leg pain relating to the lumbar disk herniation. Methods Mepacrine was injected into cavum epidurale of rats transplanted with autologous nucleus pulposus. The major electrophysiologic parameters of cuada equina was determined. Results The major electro-physiologic parameters of rats with autologous nucleus pulposus trans-planted into cavum epidurale was impaired significantly. After mepacrine, the phospholipase A2 inhibitor, injection, rats' electrophysiologic para-meters was relieved significantly. There were significant difference as compared to nucleus pulposus group(P<0.05). Conclusions Phospholipase A2 play an important role in the pathomchanism of low back pain and leg pain relating to the lumbar disk herniation. Research for more effective inhibitors of phospholipase A2 may improve the treatment for low back and leg pain.

关 键 词：米帕林 硬膜外移植自体髓核大鼠 马尾电生理损害 保护作用 电生理 椎间盘 磷脂酶 

分 类 号：R681.5[医药卫生—骨科学]