胃癌癌前病变的中医分型与pRb、P^(16)和CyclinD_1基因的表达关系  

The Relativity on the Syndrome of PLGC and the Protein Expression of Relative Genes

作　　者：常东 劳绍贤[2] 樊亚巍 乔丽华 陶永胜 殷旭红 

机构地区：[1]武警广东边防总队医院,深圳518029 [2]广州中医药大学脾胃研究所

出　　处：《中国中医药信息杂志》2002年第10期16-17,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：广州中医药大学"健桥"基金资助项目(№.A-010034)

摘　　要：目的:探讨胃癌癌前病变(PLGC)中医分型与基因表达的相关性,为本病中医证型的客观化开辟一条新途径。方法:采用免疫组化法检测51例PLGC患者的P16、CyclinD1、pRb基因蛋白的表达情况,并与中医辨证分型情况相比较。结果:胃热型的pRb表达明显高于血瘀型(P<0.05)。气滞型和胃热型的P16蛋白表达明显高于血瘀型(P<0.05)。结论:提示胃粘膜良性病变的加重与中医分型的演变规律可能存在一定的关系。Objective:To investigate the relativity on the TCM syndrome of PLGC and the protein expression of relative genes. Methods:The expression of P16、CyclinD1、pRb of 51 PLGC cases are detected by immunohistochemistry and are compared with the syndrome of TCM. Results:The pRb expression of stomach-heat syndrome is more evident than that of blood stasis(P<0.05). The P16 expression of stomach-heat syndrome and Qi stagnation syndrome are more evident than of blood stasis(P<0.05). Conclusion:It shows that the seriouslity of benign pathological changes of gastric mucosa are relate to change law of syndrome of TCM to some extent.

关 键 词：胃癌 胃癌癌前病变 中医分型 基因表达 P16基因 pRb基因 CYCLIND1基因 

分 类 号：R273.52[医药卫生—中西医结合]