曲唑酮治疗慢性功能性疼痛的双盲对照研究  

A double - blind study of trazodone in the treatment of persistent somatoform pain disorder

作　　者：任泽华[1] 张红梅[1] 蒋之杰[1] 王惠兰[1] 

机构地区：[1]山东省滨州市精神卫生中心,256613

出　　处：《山东精神医学》2002年第3期134-135,共2页Shangdong Archives of Psychiatry

摘　　要：目的 探讨曲唑酮与止痛剂对慢性功能性疼痛的疗效和副反应。方法 140例患者随机分为2组双盲对照,分别进行曲唑酮和去痛剂治疗4周,采用汉密尔顿抑郁量表(HAMD)和四级临床疗效评定标准进行评定,采用副反应量表(TESS)评定副反应。结果 曲唑酮的疗效明显好于去痛剂,有效率分别为92.85％、62.85％,副反应不严重。结论 曲唑酮对慢性功能性疼痛疗效肯定,副反应轻。Objective To observe the efficacy and side - effects of trazodone and analgesic in the treatment of persistent somatoform pain disorder.Methods 140 patients were randomly divided into trazodone group and analgesic group for the treatment of 4 weeks. The clinical efficacy and side - effects were evaluated with ch'nical evalusion HAMD and TESS. Results Trazodone was better than analgesic in the treatment of persistent somatoform pain disorder. The effective rate of trazodone was 92.85 % while that of analgesic was 62.85 % . Patients who were on trazodone reported slighter side effects. Conclusion Trazodone is an effective drug with few side - effect in the treatment of persistent somatoform pain disorder.

关 键 词：双盲对照研究 慢性功能性疼痛 曲唑酮 去痛剂 疗效 副反应 

分 类 号：R969.4[医药卫生—药理学] R971.4[医药卫生—药学]