正常新生儿血浆中IL-6、IL-8、TNF-α与NO的动态观察  

HIE STUDY OF PLASMA IL-6, IL-8, TNF-α and NOLEVEDS IN HEALTHY NEWBORNS

作　　者：吴广琴[1] 李丽梅 刘敬 

机构地区：[1]北京天坛医院妇产科,100050 [2]北京燕山石化医院儿科

出　　处：《新生儿科杂志》2002年第5期202-204,共3页The Journal of Neonatology

摘　　要：目的:探讨正常新生儿脐血、外周血免疫学特点,研究新生儿的免疫学状态。方法:以正常成人为对照,采用放射免疫法测定IL-6、IL-8与TNF-α,硝酸盐还原酶两点法测定NO。结果:正常新生儿脐血IL-6、IL-8与NO水平明显低于成人,而TNF-α则高于成人水平。正常新生儿外周血IL-6水平在生后一周内无明显变化,显著低于成人血浆含量,而IL-8生后一周内高于成人水平,TNF-α在生后一周内呈逐渐增高趋势,高于成人水平。结论:正常新生儿脐血免疫能力不足,生后免疫成熟是一个逐渐的过程,但已具有一定的免疫调节能力。高水平的TNF-α,低水平的IL-8对促进新生儿免疫功能的成熟具有重要意义,但亦可能与新生儿在出生过程中所经历的多种严重应激反应有关。IN order to investigate the neonatal immune characteristics with umbilical blood and serum. Normal adults were taken as control. Cord blood samples were obtained as soon as delivery to measure the level of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-alpha(TNF-a). Nitric oxide(NO)was measured with nitrate reductase. Results showde that IL-6, IL-8 and NO in cord blood were lower than those in adults. TNF-a of newborns was higher than those of adults. IL-6 had no change in the first week and it was lower significantly than that of adults. IL-8 was higher in the first week than those of adults. TNF-a rose gradually in the first week and was higher than those of adults. Conclusion: Normal newborns appear deficient immunity. Immune maturity is received gradually and appears a little bit ability of immu-noregulation after the labor.

关 键 词：新生儿 血浆 IL-6 IL-8 肿瘤坏死因子-Α 一氧化氮 白细胞介素 

分 类 号：R722.1[医药卫生—儿科]