10-甲基-PGD_2的合成子的合成  

The Synthesis of The Synthon For 1O-Methyl PGD_2

作　　者：蔡祖恽 樊中心[1] 王竟华 李思维 

机构地区：[1]中国科学院上海有机化学研究所

出　　处：《化学学报》1989年第3期262-265,共4页Acta Chimica Sinica

摘　　要：PGD_2的合成子(9)的合成是以2-甲基环戊1,3-二酮(1)为原料,经烯醇醚化、烯丙基化、酸去保护、羧基的锂铝氢还原、臭氧化、氧化、甲酰化获得。The isobutyl enol ether (2) of 2-methyl cyclopentandione-1, 3 (1)used as starting material was alkylated with allylbromide to form 3. Hydrolysis of 3 afforded the dione 4, which on reduction with LiAlH_4 gave oily diols 5. Ozonolysis of 5 inthe presence of Na_2CO_3 in methanol and dichloromethane at -78℃ produced the mixture of hemiacetals 6, which were oxidized to the compound 7 by Jones reagent. To introduce an aldehyde group next to the ketone position, 7 was reacted with ethyl formate followed by treatment with p-TsOH to give 9 which is a synthon for synthesis of 10- methyl-PGD_2.

关 键 词：甲基-PGD2 合成子 合成 

分 类 号：O629.9[理学—有机化学]