轮班作业女工排卵日前后的夜班次数对妊娠结局的影响  

The impact of night work near the day of ovulation on outcome of pregnancy

作　　者：李佩芝[1] 方自国[2] 潘小川[1] 王黎华[3] 徐希平[3] 

机构地区：[1]北京大学医学部公共卫生学院劳动卫生与环境卫生教研室,100083 [2]安徽医科大学生物医学研究所 [3]北京大学医学部公共卫生学院生态遗传与生殖研究中心

出　　处：《中华劳动卫生职业病杂志》2002年第5期369-371,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的　探讨轮班作业女工排卵日前、后的夜班次数对妊娠结局的影响。方法　以安徽某纺织厂符合研究条件的轮班作业女工作为研究队列进行问卷调查 ,了解一般信息以及某些职业因素的暴露情况。并收集每日晨尿直到临床怀孕或入队列满 1年仍未怀孕 ,同时每日记录当日班次及留尿情况。所有尿样用免疫放射测定分析方法 (IRMA)测定绒毛膜促性腺激素 (hCG)来判断研究对象是否怀孕 ,并结合卵泡刺激素 (FSH)、雌激素与孕激素的代谢产物雌酮结合物 (E1C)、孕二醇 3 葡萄糖酸甙 (PDG)等的测定来确定早期妊娠丢失。结果　以临床可见的自然流产组 (12人 )及经实验室确诊的早早孕丢失组 (18人 )为病例组 ,临床活产为对照组 (44人 )进行单因素和多因素Logistic回归分析 ,无论单因素还是多因素分析 ,在排卵日前、后 3天的夜班次数和临床可见的自然流产有关 (单因素 :OR =2 .4 8,95 %CI为 1.10～ 5 .6 0 ;多因素 :OR =3.90 ,95 %CI为 1.2 8～11.90 )。与早早孕丢失组也有一定的关系 ,但差异无显著性 (P >0 .0 5 )。结论　在轮班作业女工中 ,排卵日附近的夜班作业可能与自然流产存在一定的关系。Objective To investigate the effect of night work near the day of ovulation on outcome of pregnancy. Methods Daily early morning urine samples were collected from eligible shift women workers,and human chorionic gonadotropin(hCG),follicle-stimulating hormone(FSH),the urinary steroid metabolites of estrogen and progesterone(PDG,E1C) were measured to confirm the day of ovulation and early fetal loss(EFL).Questionnaires were used to know workshift,other occupation exposures,and related information. Results 12 clinical spontaneous abortion(SAB),18(EFL) and 44 clinical living birth were analyzed in relation to SAB,EFL and night shift near the day of ovulation by using single factor and multi-factor logistic regression.The result showed that night shift on the day of ovulation and the day before or after ovulation was related with SAB both in single- and muti-factorial analysis(single factor:OR=2.48,95%CI 1.10～ 5.60;muti-factor:OR=3.90,95%CI 1.28～11.90). Conclusion Night shift near the day of ovulation may be related to SAB.

关 键 词：轮班作业女工 排卵日 妊娠结局 夜班次数 

分 类 号：R135[医药卫生—劳动卫生]