蛇床子素对肺腺癌、肺鳞癌生长抑制作用的实验研究  

INHIBITION OF OSTHOL ON ADENOCARCINOMA AND SQUAMACARClNOMA OF LUNG

作　　者：周俊[1] 程维兴[1] 许永华[1] 张东辉[1] 王冬梅[1] 

机构地区：[1]兰州军区乌鲁木齐总医院,新疆乌鲁木齐830000

出　　处：《癌变．畸变．突变》2002年第4期231-233,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的 :观察蛇床子素对人肺鳞癌和肺腺癌的抑制作用。方法 :建立BALB/C裸鼠的人肺腺癌和肺鳞癌模型 ,给予蛇床子素 ,剂量为 1.5 μg/(g·d) ,观察瘤体的大小、重量和动物血清中肺癌标志物DR 70的水平 ,以此评价蛇床子素的抑癌作用。结果 :蛇床子素对肺鳞癌的抑瘤率为 6 9.5 % ,对肺腺癌的抑瘤率为 5 0 .0 % ,对DR 70也有显著降低作用。结论 :蛇床子素对肺鳞癌和肺腺癌的瘤体生长有一定的抑制作用 。Purpose: To observed the inhibition effect of osthol on human lung adenocarcinoma and squamacarcinoma. Methods: Set up models of human lung adenocarcinoma and squamacarcinoma on the bodies of BALB/C, one kind of nude mice, then osthol was given to the mice in the dose of 1.5 μg/ (g·d) . Antitumor effect of osthol were valued by weighing the tumor and determing DR 70, the mark of lung cancer in BALB/C serum.Results: The inhibitory rates were 69.5 % on lung squamacarcinoma, and 50 % on lung adenocarcinoma, respectively also obviously decreased the level of serum DR 70. Conclusion: Osthol can inhibite the growing of lung adenocarcinoma and lung squamacarcinoma, especially the squamacarcinoma.

关 键 词：蛇床子素 肺腺癌 肺鳞癌 实验研究 

分 类 号：R273.42[医药卫生—中西医结合] R285.5[医药卫生—中医肿瘤科]