血液和尿液中化学元素与尿石症发病关系的研究  

STUDY ON CHEMICAL ELEMENTS IN SERUM AND URINE AND UROLITHIASIS.

作　　者：张顺祥[1] 李良成[1] 沈珉[1] 张慧敏[1] 刘桂华[1] 施侣元[2] 谢建斌[1] 

机构地区：[1]深圳市卫生防疫站,518020 [2]华中科技大学流行病学教研室

出　　处：《现代预防医学》2002年第5期603-606,共4页Modern Preventive Medicine

基　　金：深圳市科委科研基金资助 (960 1)

摘　　要：目的 :探讨血、尿化学元素与尿石症发病的关系。方法 :基于医院病例对照研究设计 ,按 1∶ 1配对选取尿石症新发病人和对照 6 0对 ,收集空腹血清和尿液 ,ICP- AES法测定血清和尿液中钙、镁、钾、钠和微量元素 ,离子分析仪检测尿液中草酸、柠檬酸和尿酸 ,自由溶液毛细管电泳测定尿肌酐。结果 :血和尿液中钾、钠、钙、镁含量在病例和对照组差异无显著性意义 ,而尿钙 /镁比值尿石症病例高于对照组 ;血 12种微量元素中 ,除钴和锶 ,其余两组差异无显著性意义 ;尿液中经肌酐调整的锂和钼病例组高于对照组 ,而锌含量病例组较低 ,其余 10种微量元素两组间差异无显著性意义 ;尿液中枸椽酸对照组高于尿石症病例组。结论 :血钴、锶和尿锂、钼、锌含量与尿石症发病有关 。Objective:To explore the relationship between chemical elements in serum and urine and urolithiasis.Methods:60 patients with urolithiasis were selected as cases and 60 patients without any urinary diseases were selected as controls,which were matched by age and sex.Blood and urine were collected.Inorganic elements were analyzed with ICP-AES in serum and urine.Oxalic acid,citric acid,uric acid and creatinine were detected with the capillary electrophoresis.Results:Except for the urinary Ca/Mg,differences of Ca,Mg,K,Na in serum and urine between cases and controls were not significant.Case group had lower concentration of Co and higher of Sr in serum.After adjusted by urinary creatinine,cases excrete significantly more Li and Mo,and less Zn in urine.The urinary citric acid content of cases was lower than that of controls.There were any significant differences of oxalic acid,uric acid and creatinine between two groups.Conclusion:The concentration of Co and Sr in serum and Li,Mo,Zn and citric acid in urine may influence the formation of urinary stones.

关 键 词：血液 尿液 化学元素 尿石症 枸缘酸 危险因素 ICP-AES法 

分 类 号：R691.4[医药卫生—泌尿科学]