胰岛素受体底物1基因Gly972Arg多态性与2型糖尿病不相关  

No association between the Gly972Arg polymorphism of the insulin receptor substrate 1 gene and type 2 diabetes mellitus

作　　者：王国英[1] 洪天配[1] 张路[1] 王群[1] 马征[1] 李琼芳[1] 徐希平[2] 

机构地区：[1]北京大学第三医院内分泌科,100083 [2]美国哈佛大学公共卫生学院群体遗传研究室

出　　处：《中国糖尿病杂志》2002年第5期265-267,共3页Chinese Journal of Diabetes

摘　　要：目的　探讨中国汉族人群胰岛素受体底物 1(IRS- 1)基因 Gly972 Arg多态性与 2型糖尿病的关系。　方法　选取 10 2例 2型糖尿病患者及 10 2例糖耐量正常的患者配偶进行对照研究 ,应用聚合酶链反应——限制性片断长度多态性的方法进行胰岛素受体底物 1基因 Gly972 Arg多态性位点基因型检测。　结果　 IRS- 1基因 Gly972 Arg突变频率在病例组和对照组均为 2 % ,明显低于白人。　结论　在中国汉族人群中 ,IRS- 1基因 Gly972 Arg突变不是Objective To determine the relationship of the Gly972Arg polymorphism of insulin receptor substrate 1 (IRS 1) gene with type 2 diabetes mellitus in Chinese population. Methods Genotype was evaluated by the polymerase chain reaction restriction fragment length polymorphism in 102 pairs of case control spouses. Results The frequency of Gly972Arg mutation of IRS 1 gene was 2% in type 2 diabetic patients and control subjects in Chinese, lower than in Caucasian population. Conclusion Gly972Arg polymorphism of the IRS 1 gene may not play an important role in the Chinese Han population.

关 键 词：胰岛素受体底物1 基因Gly972Arg 2型糖尿病 聚合酶链反应 限制性片断长度多态性 基因多态性 

分 类 号：R587.2[医药卫生—内分泌]