原发性高血压患者肱动脉流量介导的舒张活性变化  

Impaired brachial artery flow-mediated dilation in patients with essential hypertension

作　　者：李涵志 程旭青 朱爱华 邹文 唐晓明[2] 吴志坚[2] 

机构地区：[1]南海市南庄医院内科 [2]第一军医大学附属珠江医院心内科

出　　处：《临床心血管病杂志》2002年第10期495-497,共3页Journal of Clinical Cardiology

基　　金：广东省佛山市医学科研项目(No.99042)

摘　　要：目的:探讨原发性高血压(EH)患者内皮依赖性血管舒张功能的改变。方法:应用无创性高分辨率超声检测61例EH患者(EH组)和38例正常血压者(对照组)肱动脉流量介导的舒张(FMD)活性,以评价其血管内皮功能。结果:①对照者、Ⅰ级EH者、Ⅱ级EH者的FMD呈逐渐明显降低(P<0.05或<0.01)。②Ⅰ级、Ⅱ级EH组的FMD峰值时间较对照组均明显延迟(分别P<0.05和<0.01)。结论:EH患者存在着明显的内皮功能障碍,并随着病程进展损害逐渐加重。Objective:To explore changes of endothelium-dependent vasodilatation in essential hypertensive patients. Methods; By using high-resolution ultrasonography, vascular endothelial function of 61 patients with essential hypertension and 38 subjects as controls were studied in the form of brachial artery flow-mediated dilation (FMD). Results: ①The level of brachial artery FMD showert a progressive reduction between the normal control group, phase Ⅰ and phase Ⅱessential hypertension groups ( P <0. 05 or <0. 01). ② The time of maximum FMD were more remarkable delayed in phase I and phase II essential hypertension groups than that in the normal control group(P <0. 05 and 0. 01). Conclusion: There are evident dysfunctions of vascular endothelium in the essential hypertensive patients, and more worse as the hypertension progressing.

关 键 词：原发性高血压 肱动脉流量介导舒张 血管内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病]