狼疮性肾炎临床与病理分析  

Clinical and pathology on 36cases lu pus nephritis patients

作　　者：陈菊花[1] 张志胜[1] 郑东辉[1] 王洪武[1] 

机构地区：[1]江苏省淮安市第二人民医院,223002

出　　处：《中国航天医药杂志》2002年第5期42-43,共2页Medical Journal of CASE

摘　　要：目的探讨狼疮性肾炎(LN)的临床与病理,治疗效果及预后。方法对36例狼疮性肾炎进行了分析研究。结果给予口服强的松,大剂量甲基强的松龙及环磷酰胺(CTX)冲击治疗,合并肾功能衰竭配合血液透析治疗,总有效率达72.3%,死亡率16.6%。结论狼疮性肾炎及早地行肾活检,有助于诊断,经糖皮质激素和环磷酰胺治疗,大部分患者可达到完全缓解和部分缓解,病情的预后与病理类型、有无合并症及病变累及器官数量有关。Objective To study clinical and pathologic fea ture,and prognosis of lupus nephritis.Methods To analyse36cases lupus nephritis.Results Oral prednisone,pulse methylprednisolone and cyclophosphamide thera py,plus hemoclialysis treated patients with renal failure.Effective rate was 72.3%,mortality was 16.6%.Conclusion Early renal biopsy can help the diagnosis of lupus nephritis,with c orticosteroids and cyclophosphami de treatment,most patients can be re mission or partly re-mission.The prognosis associate wi th pathologic types,complications and organs involved.[

关 键 词：狼疮性肾炎 糖皮质激素 环磷酰胺 病理学 药物疗法 

分 类 号：R593.242[医药卫生—内科学] R977.1[医药卫生—临床医学]