固体碳酸盐催化烃化反应合成止咳酮的研究(Ⅰ)  

ALKYLATION IN SOLID-LIQUID TWO PHASE SYNTHESIS OF BISULFITE ADDITION PRODUCT OF 4-PHENYL-BUFANONE-2 A REMEDY FOR COUGH (Ⅰ)

作　　者：布添垣 谢思娟[1] 高志勇[1] 张少璋 

机构地区：[1]暨南大学化学系

出　　处：《暨南大学学报（自然科学与医学版）》1991年第1期73-76,共4页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：在无溶剂的条件下,采用固体碱性碳酸钾、乙酰乙酸乙酯和苄氯进行固-液相烃化反应,合成止咳酮。烃化温度115—125℃,烃化时间1.5小时,产率:40％～45％。Alkylation of ethyl acetoacetate with chlorbenzene by using low cost powdered alkali carbonate as base in the absence of solvent and catalyst, was applied to the synthesis of the addition product of bisulfite of 4-phenyl-butanone-2. The yield was 40%～45%.

关 键 词：烃化反应 止咳酮 亚硫酸氢盐 合成 

分 类 号：TQ463.24[化学工程—制药化工]