石杉碱甲联合脑蛋白水解物针剂治疗血管性痴呆的临床疗效观察  

The clinical effect observation of Huperzine A combined with cerebroprotein hydrolysate injection in treating vascular dementia

作　　者：韩菲[1] 杨飏[1] 李志云[1] 代碧芬 鲍天昊[1] 

机构地区：[1]昆明医科大学附属精神卫生中心,云南昆明650500

出　　处：《中医临床研究》2016年第12期39-41,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨石杉碱甲联合脑蛋白水解物针剂治疗血管性痴呆临床疗效。方法:选取我院老年精神病科诊断为轻、中度血管性痴呆(VD)患者60例,随机分为两组,每组30例。对照组给予口服石杉碱甲共4周,治疗组在对照组基础上静滴脑蛋白水解物针剂2周(1个疗程),治疗4周后观察两组的临床疗效,按长谷川痴呆量表(HDS)和日常生活能力评定量表(ADL)的评分标准对患者认知功能及日常生活能力进行评分,疗效判定标准采用临床总体印象量表(CGI)评定。结果:治疗组的总有效率为93.3%,显著高于对照组的76.7%(P<0.05)。ADL评分明显低于同组治疗前及对照组治疗后(P<0.01);HDS-R评分治疗后均高于治疗前,且治疗组HDS-R评分较对照组上升更明显(P<0.01)。结论:石杉碱甲联合脑蛋白水解物针剂可更有效地改善轻、中度老年血管性痴呆患者的认知功能及生活能力,优于单用石杉碱甲。Objective:To investigate the clinical effect of Huperzine A combined with cerebroprotein hydrolysate injection in treatingvascular dementia. Methods: 60 cases of patients with mild and moderate vascular dementia (VD) in our hospital were randomly dividedinto two groups, with 30 cases in each group. The control group was given oral huperzine A for a total of 4 weeks while the treatment groupreceived Huperzine A combined with cerebroprotein hydrolysate injection for 2 weeks. The clinical efficacy of the two groups wasobserved 4 weeks after the treatment, the patients recognize function and daily life ability score were evaluated by applying HasegawaDementia Scale (HDS) and activities of daily living rating scale (ADL), clinical criteria was made by using the Clinical Global ImpressionScale (CGI). Results: The total effective rate of the treatment group was 93.3%, which was significantly higher than that of the controlgroup of 76.7%, P<0.05. ADL score of the treatment group was significantly lower than that of the same group before treatment and that ofthe control group, P<0.01; HDS-R score after treatment was higher than that before treatment, and the improvement of HDS-R score of thetreatment group increased more significantly than that of the control group, P<0.01. Conclusion: Huperzine A combined withcerebroprotein hydrolysate injection could improve the recognize function and daily life ability of patients with mild and moderate vasculardementia effectively, its effect was better than that of the single application of Huperzine A.

关 键 词：血管性痴呆 石杉碱甲 脑蛋白水解物 认知功能 

分 类 号：R277.7[医药卫生—中医学]