Fe(OAc)2催化烯烃氧化裂解反应的研究  

Fe(OAc)_2-catalyzed oxidative cleavage of alkenes

作　　者：李孟顺[1,2] 胡冬燕[1,2] 周静[3] LI Meng-shun;HU Dong-yan;ZHOU Jing(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Pharmaceutical Science,Chongging Key Laboratory of Biochemistry and Molecular Pharmacology,Chongqing Medical Unirevsity,Chongqing 400016,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院大学,北京100049 [3]重庆医科大学药学院,生物化学与分子药理学重庆市高级市级重点实验室,重庆400016

出　　处：《化学研究与应用》2016年第7期1034-1038,共5页Chemical Research and Application

摘　　要：探讨了在氧气条件下,利用金属盐催化烯烃氧化裂解生成羰基化合物的反应,考察了金属催化剂种类,反应溶剂和温度等因素对反应的影响。实验结果表明,在氧气条件下(常压),以Fe(OAc)2 为催化剂,DME(二甲基乙二醚)为溶剂,温度为80 ℃时反应12 h,烯烃能够顺利转化为羰基化合物,收率为55 ~ 67%,该反应适用于二取代和单取代端烯,操作简单,所用试剂廉价易得,且对环境友好,是一种简便、绿色的合成方法。关键词:氧气;烯烃;氧化裂解;A reaction of metal-catalyzed oxidative cleavage of alkenes to carbonyl compounds in the presence of oxygen molecularwas developed. The influence of different catalysts,solvent,temperature were investigated. The results showed that the reaction usingsubstituted terminal alkenes catalyzed by Fe(OAc)2 in DME solvent at 80 ℃ for 12 h under oxygen molecular gave 55 ~ 67%yields. The protocol with priority of simple procedure,easily available substrates and environment friendly feature provided a facileand green methodology for oxidative cleavage of alkenes.

关 键 词：氧气 烯烃 氧化裂解 羰基化合物 

分 类 号：O623.12[理学—有机化学]