骨细胞程序性死亡在骨质疏松中作用的研究进展  

Effect of the programmed cell death of osteocyte on osteoporosis

作　　者：崔红旺[1] 蒋电明[1] Cui Hongwang;Jiang Dianming(Department of Orthopaedics, First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing 400016, China)

机构地区：[1]重庆医科大学附属第一医院骨科,400016

出　　处：《中华老年骨科与康复电子杂志》2016年第3期181-184,共4页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：国家自然科学基金(81171685)

摘　　要：骨质疏松症(osteoporosis,OP)是一个全球公共健康问题,其发病机制尚未完全阐明。近年来研究发现骨细胞过度死亡在OP的发病过程中起着重要的作用。随着人类对细胞死亡方式的不断认识,发现除凋亡以外,自噬和程序性坏死也被认为是细胞程序性死亡的方式。本文就骨细胞的这三种程序性死亡方式在OP发病机制中的作用进行综述。Osteoporosis is a global public health problem, the pathogenesis has not been fully elucidated yet. Osteocytes play a crucial role in the pathophysiological process of osteoporosis. Along with constantly understanding of cell death forms, autophagy and necroptosis are regarded as the other modes of programmed cell death besides apoptosis. This article reviews the roles of the three forms of cell death in the pathogenesis of osteoporosis.

关 键 词：骨质疏松症 骨细胞 凋亡 自噬 程序性坏死 

分 类 号：R580[医药卫生—内分泌]