基于雷公藤配伍前后雷公藤内酯酮含量变化探讨其减毒机制  

Discussion on the Mechanism of Reducing Poison Based on Content Changes of Triptonide Before and After Compatibility

作　　者：唐利宇 孟楣[1,2] 张贺[1] 江莹[1] 许坡 张静[1] 王芳[1] TANG Li-yu;MENG Mei;ZHANG He;JIANG Ying;XU Po;ZHANG Jing;WANG Fang(Anhui University of Chinese Medicine, Hefei 230031, China;The First Hospital Affiliated to Anhui University of Chinese Medicine,Hefei 230031, China;State Administration of National Chinese Drugs Medicament Laboratory of Grade,Hefei 230031, China;Key Laboratory of Xin'an Medicine of Ministry of Education, Hefei 230031, China)

机构地区：[1]安徽中医药大学,安徽合肥230031 [2]安徽中医药大学第一附属医院国家中医药管理局中药制剂三级实验室新安医学教育部重点实验室,安徽合肥230031

出　　处：《中国中医药信息杂志》2016年第8期87-90,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家科技支撑计划(2012BA126B03);安徽省科技厅重点实验室计划项目(10111406029)

摘　　要：目的以雷公藤内酯酮为指标,考察黄芪配伍雷公藤前后的雷公藤毒性成分的含量变化,以期推断其可能配伍减毒机制。方法采用高效液相色谱法比较分析黄芪配伍雷公藤前后毒性成分雷公藤内酯酮含量变化,从化学成分层次分析其减毒的物质基础变化,并结合中药七情中"相畏相杀"理论,推断其可能配伍减毒机制。结果含量测定试验中黄芪配伍雷公藤的雷公藤内酯酮平均含量(0.42×10^(-3) mg/m L)明显低于单味雷公藤的雷公藤内酯酮含量(0.54×10^(-3) mg/m L),说明黄芪配伍雷公藤后降低了雷公藤内酯酮的含量。结论黄芪与雷公藤配伍可降低雷公藤毒性。Objective To investigate the changes in the contents of toxic constituents of Triptergium wilfordiibefore and after the compatibility with Astragali Radix with the index of triptolide; To infer the possible compatibilitymechanism of reducing poison. Methods HPLC was used to compare and analyze the changes in the contents of toxicconstituents of Triptergium wilfordii before and after the compatibility with Astragali Radix with the index oftriptolide. Changes of material basis of reducing poison were analyzed from the level of chemical components. Thetheory of “mutual restraint between two medicines” in TCM seven emotions was combined to infer the possiblecompatibility mechanism of reducing poison. Results The average content of triptolide in compatibility with AstragaliRadix (0.42×10-3 mg/mL) was significantly lower than that in single Tripterygium wilfordii (0.54×10-3 mg/mL). Itshowed that the content of triptonide decreased after the compatibility with Astragali Radix. Conclusion Thecompatibility of Astragali Radix can reduce the toxicity of Triptergium wilfordii.

关 键 词：雷公藤内酯酮 黄芪 高效液相色谱法 相畏相杀 

分 类 号：R284.1[医药卫生—中药学]