轮状病毒及轮状病毒疫苗研究进展  

Research Progress of Rotavirus and Rotavirus Vaccine

作　　者：孙丽丽[1,2] 吴晋元[2] 孙茂盛[2] SUN Li-li;WU Jing-yuan;SUN Mao-sheng(Kunming Medical University,Kunming Yunnan 650500;Institute of Biology,Chinese Academy of Medical Science and Peking Union Medical College,Yunnan Provincial Key Laboratory of Development of Vaccines against Major Infectious Diseases,Kunming Yunnan 650118,China)

机构地区：[1]昆明医科大学,云南昆明650500 [2]中国医学科学院,北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,云南昆明650118

出　　处：《昆明医科大学学报》2016年第6期134-138,共5页Journal of Kunming Medical University

基　　金：国家级自然科学863基金资助项目(2012AA02A404);重大新药创制专项基金资助项目(2014ZX09102041004);云南省应用基础研究计划面上基金资助项目(2009CD142)

摘　　要：人轮状病毒(human rotavirus,HRV)自上世纪70年代初发现以来,至今仍然是世界范围内引起5岁以下婴幼儿腹泻的最主要病原体,每年约60万婴幼儿因轮状病毒感染导致严重脱水死亡。由于轮状病毒腹泻尚无特异性治疗药物,使用疫苗预防轮状病毒感染是目前有效手段.一种疫苗的研究往往涉及了多学科理论和技术,就轮状病毒流行情况、动物实验模型、机体感染后的免疫应答及疫苗研发使用等相关问题作一综述。Human rotavirus has been discovered since the early 1970s,which is still a primary pathogen causing infant diarrhea under the age of five. Each year about 600,000 infant died of severe body dehydration caused by rotavirus infection. Since the current rotavirus diarrhea have no specific therapeutic drugs,using vaccine to prevent rotavirus infection is an effective method. Research on a vaccine often involved in a multidisciplinary theory and technology. This article reviewed the epidemic situation of rotavirus,animal model,the body's immune response after infection, developing and using vaccine and other related issues.

关 键 词：人轮状病毒 疫苗 婴幼儿 腹泻 

分 类 号：R373.2[医药卫生—病原生物学]