rhBNP治疗高龄女性急性非ST抬高性心肌梗死临床观察  

Clinical Observation of rhBNP in the Treatment of Acute NSTEMI in the Elderly

作　　者：陆锐[1] 张文超[1] 李欣[1] 田颖[1] Lu Rui;Zhang Wen-chao;Li Xin;Tian Ying(Department of Cardiology, Beijing No. 6 Hospital, Beijing 100007, China)

机构地区：[1]北京市第六医院心内科,北京100007

出　　处：《中国医药导刊》2016年第7期673-674,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨冻干重组人脑利钠肽(新活素,rh BNP)治疗高龄女性非ST抬高急性心肌梗死(NSTEMI)的有效性。方法:96例NSTEMI女性患者,随机分为rh BNP组和RT组(常规治疗组),rh BNP组在常规治疗基础上加用rh BNP治疗,观察两组尿量、CTNI恢复时间、住院天数、恶性心律失常发生率、死亡率、肾功能变化等。结果:rh BNP组患者比RT组治疗后尿量明显增加,差异有统计学意义[日均尿量(1315±355)ml比(2014±518)ml,P<0.01]。rh BNP组CTNI恢复时间和住院时间均短于RT组,差异有统计学意义[CTNI恢复时间(6.7±2.7)比(4.4±1.3)天,住院时间(25.6±7.8)比(20.9±6.5)天,P<0.01];两组肾功能情况治疗前后对比无统计学差异;两组恶性心律失常及死亡率方面无统计学差异。结论:高龄女性NSTEMI患者rh BNP虽不能改善住院期间死亡率,但能更好的缓解症状,缩短治疗时间,减少住院费用,是急诊PCI治疗的有效补充。Objective: To investigate the effect of lyophilized recombinant human brain natriuretic peptide(rhBNP) of non STelevation acute myocardial infarction(NSTEMI) is effective in the treatment of elderly women. Methods: 96 cases of female NSTEMIpatients were randomly divided into rhBNP group and RT group (conventional treatment group), rhBNP group in on the basis ofconventional treatment combined with rhBNP observed two groups of urine volume, cTnI recovery time, hospitalization days, malignantarrhythmia incidence rate, mortality rate, changes in renal function. Results:The urine volume of patients in group rhBNP than in groupRT after treatment was significantly increased, the difference was statistically significant [average daily urine volume (1315±355) mlvs (2014±518)ml, P<0.01]. RhBNP group cTnI recovery time and hospitalization time were shorter than the RT group, the differencehas recovery statistical significance [CTNI time (6.7±2.7) vs (4.4±1.3) day, hospitalization time (2.56±7.8) vs (20.9±6.5) day, P<0.01];before and after the two groups of renal function treatment comparison was not statistically difference; there was no significant differencetwo groups of malignant arrhythmias and mortality. Conclusion: rhBNP patients with NSTEMI in elderly women can not improvethe hospital mortality, but it can better relieve symptoms, shorten the treatment time, reduce the cost of hospitalization, is an effectivesupplement for emergency PCI treatment.

关 键 词：高龄女性 心肌梗死 BNP 重组人脑利钠肽 

分 类 号：R542.22[医药卫生—心血管疾病]